B7-2/CD86 Antibody (AP-MAB0827)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-06672
    • Availability
      Product Discontinued

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B7-2/CD86 Antibody (AP-MAB0827) Summary

Immunogen
LPS-activated mouse B cells
Marker
DC Maturation Marker
Specificity
CD86 (AP-MAB0827)
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
CD86
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
Flow Cytometry, Immunoprecipitation, Immunohistochemistry-Frozen, Blocking the mixed lymphocyte reaction in vitro and Inhibiting the priming of cytotoxic T lymphocytes in vivo (along with antibodies against B7-1).

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS - Azide free
Preservative
No Preservative
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for B7-2/CD86 Antibody (AP-MAB0827)

  • Activation B7-2 antigen
  • B70
  • B7-2 antigen
  • B72
  • B7-2
  • B-lymphocyte activation antigen B7-2
  • BU63
  • CD28 antigen ligand 2
  • CD28LG2B7-2 antigen)
  • CD86 antigen
  • CD86 molecule
  • CD86
  • CTLA-4 counter-receptor B7.2
  • FUN-1
  • LAB72
  • MGC34413
  • T-lymphocyte activation antigen CD86

Background

CD86 is an 80 kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with LPS activated mouse B cells

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Additional B7-2/CD86 Products

Bioinformatics Tool for B7-2/CD86 Antibody (NBP1-06672)

Discover related pathways, diseases and genes to B7-2/CD86 Antibody (NBP1-06672). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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PTMs for B7-2/CD86 Antibody (NBP1-06672)

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Blogs on B7-2/CD86.

CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated...  Read full blog post.

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Bioinformatics

Gene Symbol CD86
Entrez