B7-2/CD86 Antibody (AP-MAB0827)



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B7-2/CD86 Antibody (AP-MAB0827) Summary

LPS-activated mouse B cells
DC Maturation Marker
CD86 (AP-MAB0827)
Protein A purified
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Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
0.5mg antibody in 0.5 mL PBS with no preservative
No Preservative
1.0 mg/ml
Protein A purified


Application Notes
Flow Cytometry, Immunoprecipitation, Immunohistochemistry-Frozen, Blocking the mixed lymphocyte reaction in vitro and Inhibiting the priming of cytotoxic T lymphocytes in vivo (along with antibodies against B7-1).

Reactivity Notes



CD86 is an 80 kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with LPS activated mouse B cells


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Blogs on B7-2/CD86.

CD86 - I work in tandem with CD80
CD86 belongs to the immunoglobulin superfamily of proteins that drive innate and adaptive immune responses. It is an 80kD co-stimulatory molecule for the priming and activation of naive and memory T-cells, respectively. CD86 is expressed on activated...  Read full blog post.

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Gene Symbol CD86

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