B7-1/CD80 Antibody (1G10)



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B7-1/CD80 Antibody (1G10) Summary

Mouse CD80 (B7-1), Mw 45-47 kDa
Mouse CD80 (B7-1), Mr 45-47 kDa
IgG2a Kappa
Protein A or G purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
100 mM borate buffered saline, pH 8.2
No Preservative
0.5 mg/ml
Protein A or G purified


Application Notes
Use in Western blot reported in scientific literature (PMID 9053440). Use in Immunohistochemistry reported in scientific literature (PMID 9814503)


Inquire about low endotoxin, azide-free CD80 antibody.


CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. (1-4) The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. (5, 6) The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigen presenting cells. (2, 7)


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Blogs on B7-1/CD80.

CD80: A co-stimulator of T cell activation
CD80 is a 60kD single chain type I transmembrane glycoprotein that is a member of the immunoglobulin family. CD80 is expressed on activated B- and T-lymphocytes, as well as a subpopulation of previously activated B-cells, but not on the majority of re...  Read full blog post.

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Gene Symbol CD80

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