Aromatase Antibody

Images

 
Western Blot: Aromatase Antibody [NBP1-19697] - Lane1:Hela whole cell lysate. Lane2:MCF-7 whole cell lysate Lane3:PC12 whole cell lysate.
Immunohistochemistry-Paraffin: Aromatase Antibody [NBP1-19697] - Paraffin-embedded human brain tissue.
Western Blot: Aromatase Antibody [NBP1-19697] - Western blot (WB) analysis of CYP19A1 (K243) pAb in extracts from 293 cells.

Product Details

Summary
Product Discontinued
View other related Aromatase Primary Antibodies

Order Details


    • Catalog Number
      NBP1-19697
    • Availability
      Product Discontinued

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Aromatase Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 211-260 of Human CYP19A1.
Clonality
Polyclonal
Host
Rabbit
Gene
CYP19A1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of CYP19A1 (K243) pAb in extracts from 293 cells.
Immunohistochemistry (IHC) analyzes of CYP19A1 (K243) pAb in paraffin-embedded human brain tissue.
Theoretical MW
58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NBP1-19697 in the following applications:

  • IHC
    2 publications

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Aromatase Antibody

  • ARO1EC 1.14.14.1
  • Aromatase
  • AROsubfamily XIX (aromatization of androgens)
  • CYARMGC104309
  • CYPXIX
  • cytochrome P450, family 19, subfamily A, polypeptide 1
  • Cytochrome P-450AROM
  • Estrogen synthase
  • microsomal monooxygenase

Background

P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placenta, gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased aromatase activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7alpha-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D 25-hydroxylation and is localized to the mitochondria in kidney and liver.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Aromatase Antibody (NBP1-19697)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.


Filter By Application
IHC
(2)
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Filter By Species
Mouse
(1)
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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Aromatase Antibody (NBP1-19697)

Discover related pathways, diseases and genes to Aromatase Antibody (NBP1-19697). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for Aromatase Antibody (NBP1-19697)

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Blogs on Aromatase.

Aromatase - A Key Enzyme in the Biosynthesis of Estrogens
The enzyme, aromatase, belongs to cytochrome P450 family of monooxygenases known for their key role in drug catabolism and cholesterol/steroid synthesis. Aromatase uses a heme-group as a co-factor to catalyze the formation of aromatic C18 estrogens fr...  Read full blog post.

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Bioinformatics

Gene Symbol CYP19A1
Entrez
Uniprot