APRIN Antibody Pack

Product Discontinued

APRIN Antibody Pack Summary

• Immunogen: See individual datasheets
• Host: Rabbit
• Gene: PDS5B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Western Blot, Immunoprecipitation. See individual datasheets for dilutions. Other applications have not been tested.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-citrate/phosphate pH 7-8
• Preservative: 0.09% Sodium Azide
• Purity: Immunogen affinity purified

Notes

1 vial each of: NB100-754 and NB100-755.

Alternate Names for APRIN Antibody Pack

• Androgen-induced proliferation inhibitorKIAA0979androgen induced inhibitor of proliferation
• Androgen-induced prostate proliferative shutoff-associated protein AS3
• androgen-induced shutoff 3
• AS3APRIN
• CG008
• FLJ23236
• PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
• sister chromatid cohesion protein PDS5 homolog B

Background

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. Pds5B is a cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. It plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDS5B