APRIL/TNFSF13 Antibody



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APRIL/TNFSF13 Antibody Summary

A synthetic peptide C-PRARAKLNLSPHGT within the C-terminal (near) of human TNFSF13/APRIL (NP_003799.1; NP_742084.1; NP_742085.1).
Human TNFSF13 / APRIL. This antibody is expected to recognize all isoforms (alpha, beta, gamma: NP_003799.1; NP_742084.1; NP_742085.1). This antibody also cross-reacts with human, mouse and dog TNFSF12-TNFSF13 protein (GeneID: 407977, 619441, 479484; 36.6kDa, 45.9kDa, ca. 25.9kDa).
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Tris-Buffered Saline, pH 7.3, 0.5% BSA.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified

Reactivity Notes

Gorilla, Gibbon. Predicted cross-reactivity based on sequence identity: Elephant (93%), Mouse (86%), Rat (86%), Hamster (86%), Panda (86%), Canine (86%).


The T3-6 antibody recognizes human APRIL (CD256) also known as A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1, and TNFSF13. APRIL is a member of the TNF superfamily, synthesized as a type II transmembrane protein, but cleaved by furin intracellularly to become secreted factor.. Several isoforms of APRIL can be produced by alternative splicing. APRIL, like other members of the TNF ligand superfamily, forms homodimers. The reported molecular weight of an APRIL monomer is approximately 27 kD. APRIL is highly expressed in transformed cell lines, cancers of colon, thyroid, and lymphoid tissues. Monocytes and macrophages also express APRIL; expression of APRIL is down-regulated following PMA/ionomycin treatment. APRIL has been implicated in B cell development and IgA class switching, T cell survival, and the stimulation of tumor cell growth. T3-6 antibody has been shown to be useful for flow cytometry and ELISA.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol TNFSF13

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