APRIL/TNFSF13 Antibody

Images

 
Immunohistochemistry-Paraffin: APRIL/TNFSF13 Antibody [NBP1-52530] - Analysis of anti-APRIL antibody with human brain, cerebellum at concentration 5 ug/ml.
Immunohistochemistry-Paraffin: APRIL/TNFSF13 Antibody [NBP1-52530] - Staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more
Immunohistochemistry-Paraffin: APRIL/TNFSF13 Antibody [NBP1-52530] - Staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration ...read more

Product Details

Summary
Reactivity Hu, Mk, Pm, Po, Bt, BvSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

APRIL/TNFSF13 Antibody Summary

Immunogen
Synthetic peptide C-PRARAKLNLSPHGT from the C-terminus (near) of human TNFSF13 / APRIL (NP_003799.1; NP_742084.1; NP_742085.1).
Specificity
Human TNFSF13 / APRIL. This antibody is expected to recognize all isoforms (alpha, beta, gamma: NP_003799.1; NP_742084.1; NP_742085.1). This antibody also cross-reacts with human, mouse and dog TNFSF12-TNFSF13 protein (GeneID: 407977, 619441, 479484; 36.6kDa, 45.9kDa, ca. 25.9kDa).
Predicted Species
Porcine (93%), Bat (93%), Bovine (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TNFSF13
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Gorilla, Gibbon. Predicted cross-reactivity based on sequence identity: Elephant (93%), Mouse (86%), Rat (86%), Hamster (86%), Panda (86%), Canine (86%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for APRIL/TNFSF13 Antibody

  • A proliferation-inducing ligand
  • APRIL
  • APRILFLJ57090
  • CD256 antigen
  • CD256
  • TALL2
  • TALL-2
  • TNF- and APOL-related leukocyte expressed ligand 2
  • TNF-related death ligand 1
  • TNFSF13
  • TRDL1
  • TRDL-1
  • tumor necrosis factor (ligand) superfamily, member 13
  • tumor necrosis factor ligand superfamily member 13
  • tumor necrosis factor-like protein ZTNF2
  • tumor necrosis factor-related death ligand-1
  • ZTNF2

Background

The T3-6 antibody recognizes human APRIL (CD256) also known as A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1, and TNFSF13. APRIL is a member of the TNF superfamily, synthesized as a type II transmembrane protein, but cleaved by furin intracellularly to become secreted factor.. Several isoforms of APRIL can be produced by alternative splicing. APRIL, like other members of the TNF ligand superfamily, forms homodimers. The reported molecular weight of an APRIL monomer is approximately 27 kD. APRIL is highly expressed in transformed cell lines, cancers of colon, thyroid, and lymphoid tissues. Monocytes and macrophages also express APRIL; expression of APRIL is down-regulated following PMA/ionomycin treatment. APRIL has been implicated in B cell development and IgA class switching, T cell survival, and the stimulation of tumor cell growth. T3-6 antibody has been shown to be useful for flow cytometry and ELISA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TNFSF13
Entrez
Uniprot