Recombinant Human APP Protein

Product Discontinued

Recombinant Human APP Protein Summary

• Description: A recombinant protein with GST-tag at N-terminal corresponding to the amino acids 1-305 of Human APP full-length ORF
  
  

  Source: Wheat Germ (in vitro)

  Amino Acid Sequence:MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREKWYKEVHSGQARWLML

• Details of Functionality: This protein is not active and should not be used for experiments requiring activity.
• Protein/Peptide Type: Recombinant Protein
• Gene: APP

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoaffinity Purification
  • Protein Array
  • Western Blot
• Application Notes: Useful in Western Blot and ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human APP Protein

• amyloid beta (A4) precursor protein-binding, family B, member 2
• amyloid beta A4 precursor protein-binding family B member 2
• Amyloid beta precursor protein
• Amyloid beta
• APP
• beta Amyloid
• Protease Nexin II

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Publications for APP Recombinant Protein (H00000351-P02)(1)

Publication using H00000351-P02

• A Nikolaev, T McLaughlin, DD O'Leary et al. APP binds DR6 to trigger axon pruning neuron death via distinct caspases. Nature;457(7232):981-9. 2009-02-19 [PMID: 19225519]

FAQs for APP Recombinant Protein (H00000351-P02). (Showing 1 - 1 of 1 FAQ).

1. I received an inquiry from a customer about APP recombinant (1-286 aa). Could you let us know if you have (or had) such a product. The customer probably saw the following paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677572/
   • The APP recombinant protein that relates to the publication you listed is catalog # H00000351-P02. Please note this protein is amino acids 1-306 with an Ntermina GST tag.

Bioinformatics

• Gene Symbol: APP