Apolipoprotein B/ApoB Antibody (2E3)

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Summary
Product Discontinued
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    • Catalog Number
      NBP1-97423
    • Availability
      Product Discontinued

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Apolipoprotein B/ApoB Antibody (2E3) Summary

Immunogen
The antibody reacts with low density lipoproteins of human plasma.
Specificity
The antibody reacts with low density lipoproteins of human plasma. It is specific for fragment T2, the carboxyterminal thrombolytic peptide of human apo-B. No crossreactions with other human plasma proteins were detected.
Isotype
IgM Kappa
Clonality
Monoclonal
Host
Mouse
Gene
APOB
Purity
Sodium sulfate precipitation
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Applications/Dilutions

Dilutions
  • ELISA 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10
Application Notes
The antibody can be used for LDL depletion of human plasma, in combination with other antibody for detection of LDL in plasma and for the specific detection of apo-B. The antibody is also useful for detection of apo-B in tissue sections.The antibody can be used in ELISA techniques and in immunohistology on frozen sections. For depletion experiments the antibody should be used in a solid phase system.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
1 ml purified solution with 0.5 mg/ml antibody, 10mM Sodium Phosphate (pH 8.0), 0.1M NaCl and 0.1% (w/v) Mannitol
Preservative
1mM Sodium Azide
Concentration
LYOPH
Purity
Sodium sulfate precipitation
Reconstitution Instructions
Reconstitute with 1 ml sterilized water and with preservative if preferred.

Alternate Names for Apolipoprotein B/ApoB Antibody (2E3)

  • Apo B-100
  • APOB
  • apoB-100
  • apoB-48
  • apolipoprotein B (including Ag(x) antigen)
  • Apolipoprotein B
  • apolipoprotein B-100
  • apolipoprotein B48
  • FLDB
  • LDLCQ4
  • mutant Apo B 100

Background

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol APOB
Entrez