Apc11 Antibody

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Western Blot: Apc11 Antibody [NB100-78340] - MCF-7 cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-APC11 antibody. Proteins were visualized using a donkey ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-78340
    • Availability
      Product Discontinued

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Apc11 Antibody Summary

Immunogen
Recombinant (partial), N-terminal
Specificity
APC11
Clonality
Polyclonal
Host
Rabbit
Gene
ANAPC11
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Application Notes
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Positive Control
Apc11 Lysate (NBL1-07513)

Reactivity Notes

Mouse, Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Apc11 Antibody

  • anaphase promoting complex subunit 11 (yeast APC11 homolog)
  • anaphase promoting complex subunit 11
  • anaphase-promoting complex subunit 11
  • APC11 anaphase promoting complex subunit 11 homolog
  • APC11Hepatocellular carcinoma-associated RING finger protein
  • Apc11p
  • Cyclosome subunit 11
  • HSPC214
  • MGC882

Background

APC11 (anaphase-promoting complex subunit 11) is a member of the E3 enzyme family. This protein contains a RING-H2 domain and has a molecular weight of approximately 9.8 kD. The APC11 protein is distributed diffusely in the cytoplasm and is located in the nucleus with discrete accumulation in granular structures. The APC11 protein is a probable catalytic unit in the APC complex. The APC11 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC11 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. In addition to the APC complex proteins, APC11 has been shown to interact with Ubc4. The Poly6116 antibody has been shown to be useful for Western blotting of the human and mouse APC11 protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ANAPC11
Entrez