Apc1 Antibody (3.5F2)



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Apc1 Antibody (3.5F2) Summary

Human Tumor Necrosis factor a
Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis, and viral replication. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases, as well as cancer. Immunogen: Human Tumor Necrosis factor a
Protein A or G purified
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  • ELISA 1:100-1:2000
Application Notes
This antibody can be used for enzyme-linked immunosorbent assay (ELISA).Recommended antibody concentration: 0.5 mg/ml (when dissolved at 0.5 mg/ml, the BSA concentration will be 1%). • Recommended solvent; 100 mM PBS or Tris-HCl, pH 7.0 – 8.0 • Additional sodium azide ( up to 0.05%) is recommended for long term storage. • For a 0.5 mg/ml antibody concentration in 1% BSA, dissolve in 200 µl buffer. NOTE: Be careful opening the vial since the antibody resides in a vacuum.

Reactivity Notes


Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS with 1% BSA
No Preservative
0.5 mg/ml
Protein A or G purified

Alternate Names for Apc1 Antibody (3.5F2)

  • anaphase promoting complex subunit 1
  • anaphase-promoting complex 1 (meiotic checkpoint regulator)
  • anaphase-promoting complex subunit 1
  • APC1Testis-specific gene 24 protein
  • Cyclosome subunit 1
  • Mitotic checkpoint regulator


APC1 (anaphase-promoting complex subunit 1) is a meiotic checkpoint regulator that is a member of the E3 enzyme family. This protein contains Rpn1/2 repeats and has a molecular weight of approximately 216 kD. The APC1 protein is located in the nucleus during interphase, and at the centrosome during metaphase/anaphase. This protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC1 protein functions as a probable scaffold for complex assembly, a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


Isotype Controls

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Apc1 NBP1-51731

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Gene Symbol ANAPC1