Apc1 Antibody (3.5F2)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51731
    • Availability
      Product Discontinued

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Apc1 Antibody (3.5F2) Summary

Immunogen
Human Tumor Necrosis factor a
Specificity
Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis, and viral replication. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases, as well as cancer. Immunogen: Human Tumor Necrosis factor a
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ANAPC1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
Application Notes
This antibody can be used for enzyme-linked immunosorbent assay (ELISA).Recommended antibody concentration: 0.5 mg/ml (when dissolved at 0.5 mg/ml, the BSA concentration will be 1%). • Recommended solvent; 100 mM PBS or Tris-HCl, pH 7.0 – 8.0 • Additional sodium azide ( up to 0.05%) is recommended for long term storage. • For a 0.5 mg/ml antibody concentration in 1% BSA, dissolve in 200 µl buffer. NOTE: Be careful opening the vial since the antibody resides in a vacuum.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS with 1% BSA
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Apc1 Antibody (3.5F2)

  • anaphase promoting complex subunit 1
  • anaphase-promoting complex 1 (meiotic checkpoint regulator)
  • anaphase-promoting complex subunit 1
  • APC1Testis-specific gene 24 protein
  • Cyclosome subunit 1
  • Mitotic checkpoint regulator
  • TSG24MCPR

Background

APC1 (anaphase-promoting complex subunit 1) is a meiotic checkpoint regulator that is a member of the E3 enzyme family. This protein contains Rpn1/2 repeats and has a molecular weight of approximately 216 kD. The APC1 protein is located in the nucleus during interphase, and at the centrosome during metaphase/anaphase. This protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC1 protein functions as a probable scaffold for complex assembly, a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Apc1 NBP1-51731

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Bioinformatics

Gene Symbol ANAPC1