Recombinant Human Annexin V Protein [Allophycocyanin]

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-91286
    • Availability
      Product Discontinued

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Recombinant Human Annexin V Protein [Allophycocyanin] Summary

Description
A Recombinant Protein to Annexin V.
Preparation
Method
E. coli
Details of Functionality
Annexin V exhibits anti-phospholipase activity and binds to phosphatidylserine (PS).
Protein/Peptide Type
Recombinant Protein
Gene
ANXA5

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50 mM TRIS, 100 mM NaCl, 1% BSA pH 7.4
Preservative
0.02% Sodium Azide

Alternate Names for Recombinant Human Annexin V Protein [Allophycocyanin]

  • Anchorin CII
  • annexin A5
  • Annexin V
  • annexin-5
  • ANX5
  • ANXA5
  • ANXV
  • Calphobindin I
  • Endonexin II
  • ENX2CBP-I
  • Lipocortin V
  • PAP-I
  • Placental anticoagulant protein 4
  • Placental anticoagulant protein I
  • PP4
  • Thromboplastin inhibitor
  • VAC-alpha
  • Vascular anticoagulant-alpha

Background

Annexins are a family of calcium-dependent phospholipid-binding proteins, which bind to phosphatidylserine (PS) to identify apoptotic cells. In healthy cells, PS is predominantly located along the cytosolic side of the plasma membrane. Upon initiation of apoptosis, PS loses its asymmetric distribution in the phospholipid bilayer and translocates to the extracellular membrane, which is detectable with fluorescently labeled Annexin V. In early stages of apoptosis, the plasma membrane excludes viability dyes such as propidium iodide (PI) and 7-AAD, therefore cells which display only Annexin V staining (PI/7-AAD negative) are in early stages of apoptosis. During late-stage apoptosis, loss of cell membrane integrity allows Annexin V binding to cytosolic PS, as well as cell uptake of PI and 7-AAD. Annexin V staining, paired with 7-AAD or PI is widely used to identify apoptotic stages by flow cytometry.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol ANXA5
Entrez