Angiopoietin-2 Antibody

Images

 
Immunohistochemistry-Paraffin: Angiopoietin-2 Antibody [18860002] - Human liver cancer. Hepatocellular carcinomas were distinctly stained with granular appearance in the cytoplasm. Among the other cancer tissues, ...read more
Immunohistochemistry-Paraffin: Angiopoietin-2 Antibody [18860002] - Normal tissues showed cytoplasmic staining of variable intensity, accompanied with nuclear or membranous positivity. Strong cytoplasmic staining was ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      18860002
    • Availability
      Product Discontinued

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Angiopoietin-2 Antibody Summary

Immunogen
In vivo generated recombinant protein fragment.
Localization
Nonmembrane Protein
Specificity
QC tested by ELISA using a recombinant protein
Clonality
Polyclonal
Host
Rabbit
Gene
ANGPT2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This product is useful in ELISA, Immunohistochemistry-Paraffin and Western Blot.
Publications
Read Publications using 18860002.

Reactivity Notes

THis product is reactive in Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for Angiopoietin-2 Antibody

  • AGPT2
  • ANG2
  • ANG-2
  • angiopoietin 2
  • Angiopoietin-2
  • angiopoietin-2a
  • angiopoietin-2B
  • angiopoitin 2
  • ANGPT2
  • Tie2-ligand

Background

Angiopoietin 2 and angiopoietin 1 have an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. The coiled coil domains mediate ligand homo-oligomerization and the fibrinogen-like domains mediate ligand activity. Recombinant human angiopoietin 2 has a molecular mass of approximately 66 kDa in SDS-PAGE under reducing and non-reducing conditions. Human and mouse angiopoietin 2 share 85% sequence identity and are 60% identical to their Ang1 homologs. Angiopoietin 2 and angiopoietin 1 are closely related endothelial cell-specific ligands of the endothelial cellspecific receptor Tie2 expressed on endothelial cells and early hematopoietic cells. Ang1, Ang2, and their receptor Tie2 play critical roles in embryogenic angiogenesis, adult vasculogenesis, and endothelial cell proliferation. Angiopoietin2, released by endothelial cells of interior tumor vessels, promotes vessel regression and disassociation from surrounding tumor cells. Both Ang1 and Ang2 induce phosphorylation of expressed receptors on NIH3T3 fibroblasts stably expressing transfected Tie2. However, only Ang1 induces a chemotactic response and Tie2 phosphorylation on endothelial cells. Ang2 inhibits Ang1 induced endothelial cell responses mediated by Tie2. Angiopoietin 2 probably acts as a natural antagonist for Ang1 and Tie2 both in vivo and in vitro. In adult mice and humans, angiopoietin 2 is expressed at sites of vascular remodeling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Angiopoietin-2 Antibody (18860002)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics Tool for Angiopoietin-2 Antibody (18860002)

Discover related pathways, diseases and genes to Angiopoietin-2 Antibody (18860002). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Angiopoietin-2 Antibody (18860002)

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Bioinformatics

Gene Symbol ANGPT2
Entrez