Angiopoietin-2 Antibody Summary
In vivo generated recombinant protein fragment.
QC tested by ELISA using a recombinant protein
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified
This product is useful in ELISA, Immunohistochemistry-Paraffin and Western Blot.
THis product is reactive in Human.
Alternate Names for Angiopoietin-2 Antibody
- angiopoietin 2
- angiopoitin 2
Angiopoietin 2 and angiopoietin 1 have an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. The coiled coil domains mediate ligand homo-oligomerization and the fibrinogen-like domains mediate ligand activity. Recombinant human angiopoietin 2 has a molecular mass of approximately 66 kDa in SDS-PAGE under reducing and non-reducing conditions. Human and mouse angiopoietin 2 share 85% sequence identity and are 60% identical to their Ang1 homologs. Angiopoietin 2 and angiopoietin 1 are closely related endothelial cell-specific ligands of the endothelial cellspecific receptor Tie2 expressed on endothelial cells and early hematopoietic cells. Ang1, Ang2, and their receptor Tie2 play critical roles in embryogenic angiogenesis, adult vasculogenesis, and endothelial cell proliferation. Angiopoietin2, released by endothelial cells of interior tumor vessels, promotes vessel regression and disassociation from surrounding tumor cells. Both Ang1 and Ang2 induce phosphorylation of expressed receptors on NIH3T3 fibroblasts stably expressing transfected Tie2. However, only Ang1 induces a chemotactic response and Tie2 phosphorylation on endothelial cells. Ang2 inhibits Ang1 induced endothelial cell responses mediated by Tie2. Angiopoietin 2 probably acts as a natural antagonist for Ang1 and Tie2 both in vivo and in vitro. In adult mice and humans, angiopoietin 2 is expressed at sites of vascular remodeling.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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