Als2 Overexpression Lysate (Denatured)

Images

 
Western Blot: Als2 Overexpression Lysate [H00057679-T01] - Lane 1: ALS2 transfected lysate (136.18 KDa) Lane 2: Non-transfected lysate.
Western Blot: Als2 Overexpression Lysate [H00057679-T01] - ALS2 transfected lysate.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB

Order Details

Als2 Overexpression Lysate (Denatured) Summary

Description
Pasmid: pCMV-ALS2 full-length
Gene
ALS2

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).

Lysate Details for Als2

Type
Overexpression
Protein State
Denatured

Notes

Quality control test: Transient overexpression cell lysate was tested with Anti-ALS2 antibody by Western Blots.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Als2 Overexpression Lysate (Denatured)

  • ALS2CR6
  • alsin
  • ALSJ
  • amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6
  • amyotrophic lateral sclerosis 2 (juvenile)
  • Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein
  • Amyotrophic lateral sclerosis 2 protein
  • FLJ31851
  • IAHSP
  • KIAA1563
  • MGC87187
  • PLSJ

Background

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

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Video Protocols

WB Video Protocol

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Amyotrophic Lateral Sclerosis Infographic
Amyotrophic lateral sclerosis is a neurological disease which impacts motor neurons that are involved in muscle movement throughout the body. The progressive degeneration of neurons causes weakened muscles and can lead to paralysis. There is no cure f...  Read full blog post.

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Bioinformatics

Gene Symbol ALS2