alpha-Methylacyl-CoA Racemase/AMACR Antibody [Biotin]

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Order Details


    • Catalog Number
      NBP2-34514B
    • Availability
      Product Discontinued

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alpha-Methylacyl-CoA Racemase/AMACR Antibody [Biotin] Summary

Immunogen
A synthetic peptide from human AMACR protein
Localization
Cytoplasmic
Marker
Prostate Cancer Marker
Specificity
This antibody recognizes a protein of 54kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AMACR
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
Biotin
Format
Biotin (A=N/A, E=N/A)
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry-Paraffin
Application Notes
Immunohistochemistry (Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes)
Theoretical MW
54 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Readout System

Alternate Names for alpha-Methylacyl-CoA Racemase/AMACR Antibody [Biotin]

  • 2-methylacyl-CoA racemase
  • alpha-methylacyl-CoA racemase
  • alpha-Methylacyl-CoA Racemase/AMACR
  • alphaMethylacylCoARacemase
  • AMACR
  • AMACRD
  • CBAS4
  • EC 5.1.99.4
  • RACE
  • RM

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for alpha-Methylacyl-CoA Racemase/AMACR Antibody (NBP2-34514B) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol AMACR
Entrez
Uniprot

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