alpha-Fetoprotein/AFP Antibody

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Immunohistochemistry-Paraffin: alpha-Fetoprotein/AFP Antibody [NLS2566] - Analysis of anti-NR5A2 antibody with human liver at 10 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Eq, Mk, Pm, Ch, Fi, Op, Sh, Tr, Xp, ZeSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

alpha-Fetoprotein/AFP Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human NR5A2.
Specificity
Human NR5A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Xenopus (94%), Turkey (94%), Sheep (94%), Chicken (94%), Zebrafish (94%), Fish (94%), Opossum (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AFP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10-1:500
Positive Control
alpha-Fetoprotein/AFP Lysate (NBL1-07375)

Reactivity Notes

Chimpanzee, Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (100%), Panda (100%), Platypus (94%), Trout (94%), Pufferfish (94%), Stickleback (94%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for alpha-Fetoprotein/AFP Antibody

  • AFP
  • Alpha-1-fetoprotein
  • alpha-fetoglobulin
  • alpha-Fetoprotein
  • DSCAM2
  • FETA
  • HP
  • HPAFP

Background

Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as human B1-binding factor (HB1F), CYP7A promoter-binding factor (CPF), and liver receptor homolog 1 (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis. Ftf has been shown to regulate aromatase activities in adipose tissue, and alterations in Ftf expression and/or activity in adipose tissue could have considerable effects on local estrogen production and breast cancer development. LRH has been shown to expressly strongly in gonadal tissues, and may play an important role in the regulation of gonadal function. Three isoforms of Ftf have been identified: wild type (495 aa), CPF variant 1 (contains a 46-aa insertion in the A/B domain), and CPF variant 2 (contains a 172-aa deletion within the D/E domain). Ftf expression has been documented in human adrenal, liver, ovary, testis, and pancreas. ESTs have been isolated from normal human brain, liver/spleen, embryo and uterus tissue libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Mk, Pm, Ch, Fi, Op, Sh, Tr, Xp, Ze
Applications: IHC-P

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol AFP
Entrez
Uniprot