Alpha Actinin 3 Antibody

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Western Blot: Alpha Actinin 3 Antibody [NB100-92434] - Extracts from HT-29 cells.
Western Blot: Alpha Actinin 3 Antibody [NB100-92434] - Extracts from PC12 cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-92434
    • Availability
      Product Discontinued

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Alpha Actinin 3 Antibody Summary

Immunogen
Synthetic peptide, corresponding to the N-terminus of Human Actinin-alpha3.
Clonality
Polyclonal
Host
Rabbit
Gene
ACTN3
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
Theoretical MW
103 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Alpha Actinin 3 Antibody

  • actinin, alpha 3
  • Alpha-actinin skeletal muscle isoform 3
  • alpha-actinin skeletal muscle
  • alpha-actinin-3
  • F-actin cross-linking protein
  • MGC117002
  • MGC117005

Background

Focal adhesions were identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex, which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and alpha-actinin. In addition, vinculin, Talin and alpha-actinin each contain Actin binding sites. Expression of vinculin and Talin have been shown to be affected by the level of Actin expression. alpha-actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and talin complex or by a direct interaction with integrin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Alpha Actinin 3 NB100-92434

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Bioinformatics

Gene Symbol ACTN3
Entrez
Uniprot