ALK/CD246 Antibody

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Immunohistochemistry-Paraffin: ALK Antibody [NB120-4061] - Staining of Human Tonsil stained with BAK antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

ALK/CD246 Antibody Summary

Immunogen
Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the c-terminus of the NPM-Alk transcript.
Localization
Cell Membrane
Specificity
This reacts with an 80 kDa protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ALK
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:50 - 1:100
  • Immunohistochemistry-Paraffin 1:50 - 1:100
Application Notes
Immunohistochemistry paraffin and frozen Optimal working dilutions should be determined by end user.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
Sodium Azide
Purity
IgG purified

Alternate Names for ALK/CD246 Antibody

  • ALK tyrosine kinase receptor
  • ALK
  • anaplastic lymphoma kinase (Ki-1)
  • Anaplastic lymphoma kinase
  • anaplastic lymphoma receptor tyrosine kinase
  • CD246 antigen
  • CD246
  • EC 2.7.10.1
  • Ki-1
  • NBLST3
  • Tcrz

Background

Anaplastic lymphoma kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. ALK and LTK (leukocyte tyrosine kinase) are receptor tyrosine kinases similar to the insulin receptor subfamily of kinases. LTK is found in murine B Lymphocyte precursors and in forebrain neurons. ALK is usually found in the nervous system. A truncated form of ALK occurs in many non Hodgkin's lymphomas. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 [t(2;5}], the ALK gene fuses with the NPM gene. NPM, also known as B23, is an ubiquitous nucleolar phosphoprotein involved in the transport of pre ribosomal components between the nucleolus and the cytoplasm. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK. Karpas 299 and SUDHL1 lymphoid cell lines strongly express NPM ALK.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ALK
Entrez