Aldo-keto Reductase 1C1/AKR1C1 Antibody (X 197)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, IHC-Fr, IHC-P
Clone
X 197
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Aldo-keto Reductase 1C1/AKR1C1 Antibody (X 197) Summary

Immunogen
The antibody reacts with the C9 antigen.
Specificity
Human C9 is a soluble glycoprotein of 61 kD. It is the last component in the assembly of the membrane attack complex (MAC). When the complement is activated on target membranes, multiple copies of C9 bind to the C5b-8 complex and assemble the barrel-shaped pore which causes cell lysis. The conformation of C9 changes from globular to a tubular form. The binding of C9 to C5b-8 plays a key role in the function of C9.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AKR1C1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
The antibody can be used for immuno assays, flow cytometry and Western blotting. Furthermore the antibody is useful for immunohistology on frozen and paraffin sections and inhibition of C9 binding to C5b-8.For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts C9 to be inactivated.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS, containing 0.1% bovine serum albumin.
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for Aldo-keto Reductase 1C1/AKR1C1 Antibody (X 197)

  • 20 alpha-hydroxysteroid dehydrogenase
  • 20-ALPHA-HSD
  • 20-alpha-hydroxysteroid dehydrogenase
  • 2-ALPHA-HSD
  • AKR1C1
  • Aldo-keto Reductase 1C1
  • aldo-keto reductase family 1 member C1
  • aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha(3-alpha)-hydroxysteroid dehydrogenase)
  • AldoketoReductase 1C1
  • C9
  • Chlordecone reductase homolog HAKRC
  • DD1/DD2
  • DD1MGC8954
  • DDH1
  • DDHH-37
  • dihydrodiol dehydrogenase 1
  • Dihydrodiol dehydrogenase 1/2
  • dihydrodiol dehydrogenase isoform DD1
  • EC 1.1.1
  • EC 1.1.1.-
  • EC 1.1.1.112
  • EC 1.1.1.149,2-ALPHA-HSD
  • EC 1.3.1.20
  • HAKRC
  • HAKRCDDH1aldo-keto reductase C
  • HBAB
  • hepatic dihydrodiol dehydrogenase
  • High-affinity hepatic bile acid-binding protein
  • Indanol dehydrogenase
  • MBAB
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
  • type II 3-alpha-hydroxysteroid dehydrogenase

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AKR1C1
Entrez