Aldo-keto Reductase 1B10/AKR1B10 Antibody [FITC]

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Order Details


    • Catalog Number
      NBP1-44998F
    • Availability
      Product Discontinued

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Aldo-keto Reductase 1B10/AKR1B10 Antibody [FITC] Summary

Immunogen
A highly specific 15 amino acid portion of human AKR1B10 (within amino acids 100-150). [UniProt# O60218]
Localization
Cytoplasm
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AKR1B10
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This AKR1B10 antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry frozen sections, Immunohistochemistry paraffin embedded sections, Immunoprecipitation and Western Blot analysis where a band can be seen at ~36 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Reacts with human. Does not cross react with mouse, rat or rabbit.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Aldo-keto Reductase 1B10/AKR1B10 Antibody [FITC]

  • AKR1B10
  • AKR1B11
  • AKR1B12
  • Aldo-keto Reductase 1B10
  • aldo-keto reductase family 1 member B10
  • aldo-keto reductase family 1, member B10 (aldose reductase)
  • aldo-keto reductase family 1, member B11 (aldose reductase-like)
  • AldoketoReductase 1B10
  • aldose reductase-like 1
  • aldose reductase-like peptide
  • Aldose reductase-like
  • Aldose reductase-related protein
  • ALDRLn
  • ARL1
  • ARL-1SI reductase
  • ARP
  • EC 1.1.1
  • EC 1.1.1.-
  • EC 1.1.1.21
  • hARP
  • HIS
  • HSI
  • MGC14103
  • Small intestine reductase

Background

AKR1B10 (aldo-keto reductase 1B10) is a monomeric enzyme that reduces aliphatic and aromatic aldehydes as well as certain hexoses thereby playing a critical role in detoxification of dietary/cellular alpha or beta-unsaturated carbonyls and lipid peroxides (LPOs) ultimately leading to host cells protection against carbonyl lesions. AKR1B10 is active against polycyclic aromatic hydrocarbon (PAHs) which are potent procarcinogens and against all-trans-retinal, the signaling molecule retinoic acid's precursor which regulates cellular proliferation and differentiation. AKR1B10 is a cytosolic protein, but gets secreted through lysosome-mediated mechanisms and in normal tissues, it is expressed in colon, small intestine, adrenal gland etc., whereas its expression gets upregulated in lung bronchial epithelium of cigarette smokers further augmenting the risk of PAHs mediated initiation of carcinogenesis. Moreover, AKR1B10 is overexpressed in certain cancers such as liver, breast and lung cancer, and because of its reducing potential for C13 ketonic groups of daunorubicin and idarubicin, it may provide chemoresistance for cancer cells to these drugs. Moreover, upregulated AKR1B10 in malignant cells blocks ubiquitin-dependent degradation of ACCA (acetyl-CoA carboxylase-alpha) thereby promoting fatty acid/lipid synthesis which is essential to cancer cell growth and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AKR1B10
Entrez