ALDH2 Antibody (4H2)

Images

 
Immunocytochemistry/ Immunofluorescence: ALDH2 Antibody (4H2) [NBP2-02102] Staining of COS7 cells transiently transfected by pCMV6-ENTRY ALDH2.
Flow Cytometry: ALDH2 Antibody (4H2) [NBP2-02102] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-ALDH2 antibody, and then analyzed ...read more
Immunocytochemistry/ Immunofluorescence: ALDH2 Antibody (4H2) [NBP2-02102] - Immunofluorescent staining of HepG2 cells using anti-ALDH2 mouse monoclonal antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF
Clone
4H2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

ALDH2 Antibody (4H2) Summary

Immunogen
Full length human recombinant protein of human ALDH2 (NP_000681) produced in HEK293T cell.
Isotype
IgG3
Clonality
Monoclonal
Host
Mouse
Gene
ALDH2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:50-100

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for ALDH2 Antibody (4H2)

  • acetaldehyde dehydrogenase 2
  • aldehyde dehydrogenase 2 family (mitochondrial)
  • aldehyde dehydrogenase, mitochondrial
  • ALDH class 2
  • ALDH-E2
  • ALDHI
  • ALDM
  • EC 1.2.1
  • EC 1.2.1.3
  • liver mitochondrial ALDH
  • MGC1806
  • nucleus-encoded mitochondrial aldehyde dehydrogenase 2

Background

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ALDH2
Entrez