AKR1B1 Antibody

Images

 
Western Blot: AKR1B1 Antibody [NBP1-00709] - Analysis of AKR1B1 (K275) antibody in extracts from HUVEC cells.
Immunohistochemistry-Paraffin: AKR1B1 Antibody [NBP1-00709] - Analyzes of AKR1B1 (K275) antibody in paraffin-embedded human lung carcinoma tissue.

Product Details

Summary
Product Discontinued
View other related AKR1B1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-00709
    • Availability
      Product Discontinued

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AKR1B1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 240-290 of Human AKR1B1.
Clonality
Polyclonal
Host
Rabbit
Gene
AKR1B1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Aldose Reductase (K275) pAb in extracts from HUVEC cells.
Immunohistochemistry (IHC) analyzes of Aldose Reductase (K275) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP1-00709 in the following applications:

  • WB
    1 publication

Reactivity Notes

This antibody is reactive against Human, Rat

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for AKR1B1 Antibody

  • ADR
  • Aldehyde reductase
  • Aldo-keto reductase family 1 member B1
  • aldo-keto reductase family 1, member B1 (aldose reductase)
  • ALDR1aldose reductase
  • ALR2
  • ARaldehyde reductase 1
  • EC 1.1.1
  • EC 1.1.1.21
  • Lii5-2 CTCL tumor antigen
  • low Km aldose reductase
  • MGC1804

Background

Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa, catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase, bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for AKR1B1 Antibody (NBP1-00709)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.


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WB
(1)
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Rat
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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol AKR1B1
Entrez
Uniprot