AHR Antibody Summary
Synthetic 20 amino acid peptide from internal region of human Aryl Hydrocarbon Receptor.
Human Aryl Hydrocarbon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Primate (95%), Monkey (95%). Backed by our 100% Guarantee.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Immunohistochemistry-Paraffin 6 ug/ml
Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Marmoset (95%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.1% Sodium Azide
Immunogen affinity purified
Alternate Names for AHR Antibody
- Ah receptor
- aryl hydrocarbon receptor
- bHLHe76aromatic hydrocarbon receptor
- Class E basic helix-loop-helix protein 76
The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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