AGPAT6 Antibody [FITC]

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Product Details

Summary
Product Discontinued
View other related AGPAT6 Primary Antibodies

Order Details


    • Catalog Number
      NB100-2389F
    • Availability
      Product Discontinued

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AGPAT6 Antibody [FITC] Summary

Immunogen
A synthetic peptide made to an N-terminal portion of human AGPAT6 (between residues 1-100). [Swiss-Prot Q86UL3]
Localization
Membrane
Predicted Species
Rat (100%), Porcine (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AGPAT6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10 - 1:500
Application Notes
This AGPAT6 antibody is useful for Western blot, where a band is seen at ~58 kDa representing AGPAT6 protein. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, monkey and mouse. Predicted to react with bovine, porcine, and rat based on 100% sequence homology.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for AGPAT6 Antibody [FITC]

  • 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acidacyltransferase, zeta)
  • Acyl-CoA:glycerol-3-phosphate acyltransferase 4
  • DKFZp586M1819,1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
  • EC 2.3.1.15
  • glycerol-3-phosphate acyltransferase 4,1-AGP acyltransferase 6
  • glycerol-3-phosphate acyltransferase 6,1-AGPAT 6
  • GPAT4,1-acylglycerol-3-phosphate O-acyltransferase 6
  • LPAAT-zetaLPAATZ
  • Lysophosphatidic acid acyltransferase zeta
  • testis spermatogenesis apoptosis-related protein 7
  • TSARG7

Background

Member of 1-acylglycerol-3-phosphate-O-acyltransferase (AGPATs) family, AGPAT6 (glycerol-3-phosphate acyltransferase 4) is an enzyme essential for biosynthesis of glycerolipids and triacylglycerol in eukaryotes, as well as for catalyzing the conversion of lysophosphatidic acid to phosphatidic acid. It esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, which is a required step in glycerolipid biosynthesis. AGPAT6 is active against both saturated as well as unsaturated long-chain fatty acyl-CoAs and is inhibited by N-ethylmaleimide (NEM). Its HXXXXD motif is critical for its acyltransferase activity and constitutes the site for binding of glycerol-3-phosphate's phosphate moiety. Localized in ER membrane as multi-pass membrane protein, AGPAT6 is ubiquitously expressed with relatively high expression levels in skeletal muscle, heart, mammary epithelium and testis. AGPAT6 contributes to the production of milk fat and has been considered a candidate gene for regulating milk composition. Mouse model deficient in AGPAT6 exhibit weight loss and resistance to both diet-induced as well as genetically induced obesity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AGPAT6