Aggrecan Antibody (HAG7E1)

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Product Details

Summary
Reactivity Hu, Bv, Ch(-), Fi(-), Rt(-)Species Glossary
Applications WB, ELISA, IHC, IHC-Fr, IP
Clone
HAG7E1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Aggrecan Antibody (HAG7E1) Summary

Immunogen
Human cartilage aggrecan.
Epitope
The antibody does not bind the recombinant bacterial fragments corresponding to the G1, E2 and keratin sulfate-bearing region of the aggrecan core protein. Neither does it react with chondroitin sulfate linkage regions. Transmission electron microscopy in
Marker
Chondrocyte Marker
Specificity
The recognizes human aggrecan, a proteoglycan component of cartilage matrix. The reacts with both adult and fetal cartilage matrix in immunohistology.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ACAN
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

Reacts with Human. Cross reacts with Bovine. Does not react with Chicken, Fish or Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2M Tris/HCl (pH 7.4) and 5 - 10% fetal Bovine serum (FBS)
Preservative
0.09% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for Aggrecan Antibody (HAG7E1)

  • ACAN
  • AGC1
  • AGC1SEDK
  • aggrecan core protein
  • Aggrecan
  • Cartilage-specific proteoglycan core protein
  • Chondroitin sulfate proteoglycan 1
  • Chondroitin sulfate proteoglycan core protein 1
  • CSPCP
  • CSPG1
  • CSPG1aggrecan 1
  • CSPGCP
  • large aggregating proteoglycan
  • MSK16
  • MSK16AGCAN
  • SEDK

Background

Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Aggrecan Antibody (NB120-179)

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Diseases for Aggrecan Antibody (NB120-179)

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PTMs for Aggrecan Antibody (NB120-179)

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Blogs on Aggrecan.

Aches & Pains: Aggrecan in Joint Disease and Osteoarthritis
Aggrecan is essential for the normal function of articular cartilage and intervertebral discs. Aggrecan provides the ability for the tissues to withstand compressive loading. This property is dependent on both the high charge density endowed by its nu...  Read full blog post.

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Bioinformatics

Gene Symbol ACAN
Entrez
Uniprot