Aggrecan Antibody (HAG7E1) Summary
Human cartilage aggrecan.
The antibody does not bind the recombinant bacterial fragments corresponding to the G1, E2 and keratin sulfate-bearing region of the aggrecan core protein. Neither does it react with chondroitin sulfate linkage regions. Transmission electron microscopy in
The recognizes human aggrecan, a proteoglycan component of cartilage matrix. The reacts with both adult and fetal cartilage matrix in immunohistology.
Tissue culture supernatant
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.2M Tris/HCl (pH 7.4) and 5 - 10% fetal Bovine serum (FBS)
0.09% Sodium Azide
Tissue culture supernatant
- Western Blot 1:100-1:2000
- ELISA 1:100-1:2000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
- Immunoprecipitation 1:10-1:500
Reacts with Human. Cross reacts with Bovine. Does not react with Chicken, Fish or Rat.
Alternate Names for Aggrecan Antibody (HAG7E1)
- aggrecan core protein
- Cartilage-specific proteoglycan core protein
- Chondroitin sulfate proteoglycan 1
- Chondroitin sulfate proteoglycan core protein 1
- CSPG1aggrecan 1
- large aggregating proteoglycan
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Applications: WB, IHC, ICC
Applications: WB, ICC
Applications: WB, Simple Western, IHC
Species: Hu, Rt, Bv, Rb
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Rt
Applications: WB, ELISA, S-ELISA
Applications: WB, IP
Publications for Aggrecan Antibody (NB120-179) (0)
There are no publications for Aggrecan Antibody (NB120-179).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for Aggrecan Antibody (NB120-179) (0)
There are no reviews for Aggrecan Antibody (NB120-179).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for Aggrecan Antibody (NB120-179) (0)
Additional Aggrecan Antibody (HAG7E1) Products
Related Products by Gene
, LINK PROTEIN
, MATRIX METALLOPROTEINASE 13
, MATRIX METALLOPROTEINASE 3
Bioinformatics Tool for Aggrecan Antibody (NB120-179)
Discover related pathways, diseases and genes to Aggrecan Antibody (NB120-179). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on Aggrecan.