Aggrecan Antibody (7D4)

Images

 
Western Blot: Aggrecan Antibody (7D4) [NBP2-22102] - Western Blot: Aggrecan Antibody - Recombinant human aggrecan detected with Mouse anti Human Aggrecan followed by Goat anti Mouse IgG

Product Details

Summary
Product Discontinued
View other related Aggrecan Primary Antibodies

Order Details


    • Catalog Number
      NBP2-22102
    • Availability
      Product Discontinued

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Aggrecan Antibody (7D4) Summary

Immunogen
Purified human articular cartilage aggrecan
Localization
Secreted; extracellular matrix.
Marker
Chondrocyte Marker
Specificity
Aggrecan recognises human aggrecan, a proteoglycan and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS).
Studies using a panel of core protein-directed antibodies against human aggrecan, revealed the distribution of different aggrecan isoforms within the CNS, and sub-divided the isoforms into clusters 1-5 accordingly. These studies also showed a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues. Aggrecan (7D4) recognises epitopes within the N-terminal G1-IGD-G2 region of aggrecan, that has been identified as a cluster 1 isoform.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ACAN
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

Reacts with Human. Cross reacts with Bovine. Does not react in Chicken, Fish or Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for Aggrecan Antibody (7D4)

  • ACAN
  • AGC1
  • AGC1SEDK
  • aggrecan core protein
  • Aggrecan
  • Cartilage-specific proteoglycan core protein
  • Chondroitin sulfate proteoglycan 1
  • Chondroitin sulfate proteoglycan core protein 1
  • CSPCP
  • CSPG1
  • CSPG1aggrecan 1
  • CSPGCP
  • large aggregating proteoglycan
  • MSK16
  • MSK16AGCAN
  • SEDK

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Aggrecan Antibody (NBP2-22102) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Aggrecan Antibody (NBP2-22102). (Showing 1 - 1 of 1 FAQ).

  1. What is the isotype control for NBP2-22102?
    • I would recommend our Mouse IgG1 isotype control for use with NBP2-22102. The catalog number is NBP1-96983.

Secondary Antibodies

 

Isotype Controls

Additional Aggrecan Products

Bioinformatics Tool for Aggrecan Antibody (NBP2-22102)

Discover related pathways, diseases and genes to Aggrecan Antibody (NBP2-22102). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Aggrecan Antibody (NBP2-22102)

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Pathways for Aggrecan Antibody (NBP2-22102)

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PTMs for Aggrecan Antibody (NBP2-22102)

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Research Areas for Aggrecan Antibody (NBP2-22102)

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Blogs on Aggrecan.

Aches & Pains: Aggrecan in Joint Disease and Osteoarthritis
Aggrecan is essential for the normal function of articular cartilage and intervertebral discs. Aggrecan provides the ability for the tissues to withstand compressive loading. This property is dependent on both the high charge density endowed by its nu...  Read full blog post.

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Bioinformatics

Gene Symbol ACAN
Entrez
Uniprot