AGAP2 Antibody

Images

 
Western Blot: AGAP2 Antibody [NBP1-51941] - NBP1-51941 (0.3ug/ml) staining of Human Amygdala lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated

Order Details

AGAP2 Antibody Summary

Immunogen
Peptide with sequence C-QASLDSIREAVINSQ corresponding to internal region according to NP_055585.1.
Epitope
C-QASLDSIREAVINSQ
Specificity
This antibody is expected to recognize isoform PIKE-S (NP_055585.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
AGAP2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.3 - 1 ug/ml
  • Peptide ELISA Detection limit 1:8000
Application Notes
WB: Approx. 100 kDa band observed in human brain (amygdala and cerebral cortex) lysates (calculated MW of 90.5 kDa band according to NP_055585.1).
Publications
Read Publication using NBP1-51941.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for AGAP2 Antibody

  • AGAP-2
  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
  • arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
  • centaurin, gamma 1
  • centaurin-gamma-1
  • CENTG1
  • cnt-g1
  • FLJ16430
  • GGAP2
  • GTP-binding and GTPase activating protein 2
  • GTP-binding and GTPase-activating protein 2
  • KIAA0167
  • Phosphatidylinositol-3-kinase enhancer
  • phosphoinositide 3-kinase enhancer
  • PIKEArf GAP with GTP-binding protein-like, ANK repeat and PH domains 2

Background

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity (1). PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1 (reviewed in 2). The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis (3). Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes (4). In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB100-56749
Species: Hu, Mu
Applications: WB, IHC, IHC-P
NBP2-46403
Species: Hu
Applications: IHC
NBP1-33116
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-15071
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
NBP2-46404
Species: Hu
Applications: IHC, IHC-P
AF231
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ELISA(Sta)
AF847
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
NBP1-91228
Species: Hu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
AF6260
Species: Hu
Applications: WB
NBP1-52556
Species: Hu, Mu, Po, Bt, Bv, Ca, Mk, Pm, Rb
Applications: IHC-P
NBP2-02300
Species: Hu
Applications: WB, Flow, IHC, IHC-P
NBP1-85727
Species: Hu
Applications: ICC/IF, IHC, IHC-P
NBP1-31308
Species: Hu, Mu, Rt, Bv
Applications: WB, ICC/IF, IHC, IHC-P
NB200-103
Species: Hu, Mu, Rt, Ye, Xp(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
NBP1-87757
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-21577
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
H00056731-M02
Species: Hu
Applications: WB, ELISA, ICC/IF
NBP1-77360
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP1-51941
Species: Hu
Applications: WB, PEP-ELISA

Publications for AGAP2 Antibody (NBP1-51941)(1)

Reviews for AGAP2 Antibody (NBP1-51941) (0)

There are no reviews for AGAP2 Antibody (NBP1-51941). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for AGAP2 Antibody (NBP1-51941) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional AGAP2 Products

Bioinformatics Tool for AGAP2 Antibody (NBP1-51941)

Discover related pathways, diseases and genes to AGAP2 Antibody (NBP1-51941). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for AGAP2 Antibody (NBP1-51941)

Discover more about diseases related to AGAP2 Antibody (NBP1-51941).
 

Pathways for AGAP2 Antibody (NBP1-51941)

View related products by pathway.

PTMs for AGAP2 Antibody (NBP1-51941)

Learn more about PTMs related to AGAP2 Antibody (NBP1-51941).
 

Research Areas for AGAP2 Antibody (NBP1-51941)

Find related products by research area.

Blogs on AGAP2

There are no specific blogs for AGAP2, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our AGAP2 Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol AGAP2
Entrez
Uniprot