Adiponectin/Acrp30 Antibody (RM0072-7J611)

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Immunohistochemistry-Paraffin: Adiponectin/Acrp30 Antibody (RM0072-7J611) [NBP1-21694] - The Kidney tissue samples from the Folic Acid induced kidney injury model were fixed using 4% PFA at 4C for overnight and embeded ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-21694
    • Availability
      Product Discontinued

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Adiponectin/Acrp30 Antibody (RM0072-7J611) Summary

Immunogen
Mouse recombinant Adiponectin
Specificity
This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant Adiponectin.
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
ADIPOQ
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry-Paraffin
Application Notes
This antibody detects mouse Adiponectin in Western blotting. It is crossreactive to human Adiponectin protein in Western blotting.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein G purified
Reconstitution Instructions
Reconstitute with 0.2 ml sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for Adiponectin/Acrp30 Antibody (RM0072-7J611)

  • ACDC
  • Acrp30
  • ACRP30ADPN
  • adipocyte, C1Q and collagen domain containing
  • Adiponectin
  • adiponectin, C1Q and collagen domain containing
  • AdipoQ
  • ADIPQTL1
  • ApM1
  • apM-1
  • APM1APM-1
  • C1q and collagen domain-containing protein
  • GBP28
  • GBP28apM1
  • Gelatin-binding protein

Background

Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ADIPOQ
Entrez