Adenylate Cyclase 5/6 Antibody

Images

 
Western Blot: Adenylate Cyclase 5/6 Antibody [NB100-92437] - Lane1:Hela whole cell lysate. Lane2:Raw264.7 whole cell lysate. Lane3:PC12 whole cell lysate. Lane4:Rat brain tissue lysate.
Immunohistochemistry-Paraffin: Adenylate Cyclase 5/6 Antibody [NB100-92437] - Paraffin-embedded human brain tissue.
Western Blot: Adenylate Cyclase 5/6 Antibody [NB100-92437] - (WB) analysis of A Cyclase V/VI (F1052) antibody in extracts from COLO205 cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-92437
    • Availability
      Product Discontinued

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Adenylate Cyclase 5/6 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 1111-1160 of Human ADCY 5
Clonality
Polyclonal
Host
Rabbit
Gene
ADCY5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Theoretical MW
130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB100-92437 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Adenylate Cyclase 5/6 Antibody

  • AC5
  • adenylate cyclase 5
  • adenylate cyclase type 5
  • Adenylate cyclase type V
  • Adenylyl cyclase 5
  • ATP pyrophosphate-lyase 5
  • EC 4.6.1.1

Background

Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gscoupled receptor catalyzes the exchange of GDP (bound to Galphas) for GTP, the dissociation of GTP-Galphas from Gbetagamma and Galphas-mediated activation of adenylyl cyclase. Adenylyl cyclases V (AC V) and VI (AC VI) have multiple messages. AC V and AC VI are highly expressed in heart. Unlike AC VI, AC V is expressed to a lesser extent in brain and is absent in a variety of other tissues. Both AC V and AC VI can be stimulated by NaF, guanosine 5'-[gamma-thio]triphosphoate and Forskolin but not by Ca2+/calmodulin. Activation of the D2 dopaminergic and m4 muscarine receptors inhibit the activity of adenylyl cyclase isozymes I, V, VI and VIII, whereas type II, IV and VII are stimulated and type III is not affected.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Adenylate Cyclase 5/6 Antibody (NB100-92437)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.


Filter By Application
ICC/IF
(1)
WB
(1)
All Applications
Filter By Species
Human
(1)
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Showing Publications 1 - 2 of 2.
Publications using NB100-92437 Applications Species
Oh SY, Hwang JR, Lee Y et al. Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies. Placenta 2016 Mar [PMID: 26992671]
Oh S, Hwang JR, Lee Y et al. Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies. Placenta. 2016 Jan 06 (WB, ICC/IF, Human) WB, ICC/IF Human

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Diseases for Adenylate Cyclase 5/6 Antibody (NB100-92437)

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Bioinformatics

Gene Symbol ADCY5
Entrez
Uniprot