Adenylate Cyclase 1 Antibody

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Summary
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    • Catalog Number
      NBP1-66411
    • Availability
      Product Discontinued

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Adenylate Cyclase 1 Antibody Summary

Immunogen
The antiserum was produced against synthesized peptide derived from human ADCY1. The immunogen region is: Internal.
Specificity
ADCY1 Antibody detects endogenous levels of total ADCY1 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
ADCY1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:4000
  • Western Blot 1:500-1:1000

Reactivity Notes

Human,Mouse

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Adenylate Cyclase 1 Antibody

  • 3'-5'-cyclic AMP synthetase
  • AC1
  • ADCY1
  • adenyl cyclase
  • adenylate cyclase 1 (brain)
  • Adenylate Cyclase 1
  • adenylate cyclase type 1
  • Adenylate cyclase type I
  • Adenylyl cyclase 1
  • ATP pyrophosphate-lyase 1
  • Ca(2+)/calmodulin-activated adenylyl cyclase
  • DFNB44
  • EC 4.6.1.1

Background

Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Galpha s) for GTP, the dissociation of GTP-Galpha s from Gbetagamma and Galpha s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. AC I is expressed in myenteric ganglia as two bands of 160 kDa and 185 kDa by SDS-PAGE. Ca2+ stimulation of AC I and AC III is mediated by calmodulin. Protein associated with Myc (PAM) is a very potent inhibitor of AC I. A decrease in endogenous PAM levels in HeLa cells modulate both basal and agonist stimulated cAMP accumulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ADCY1
Uniprot