Adenine Nucleotide Translocase 1 Antibody

Images

 
Immunohistochemistry: Adenine Nucleotide Translocase 1 Antibody [NB120-54418] - Detection of human ANT-1 by staining paraffin sections. Sample: Breast carcinoma (Cat# NB 820-59424). Primary antibody: Adenine Nucleotide ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Adenine Nucleotide Translocase 1 Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 2-11 of human Adenine Nucleotide Translocase 1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC25A4
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1 ug/ml
Positive Control
Adenine Nucleotide Translocase 1 Lysate (NBL1-16067)

Reactivity Notes

Expected to cross-react with Rhesus Monkey due to sequence identity.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
50mM Sodium Phosphate and 50% Glycerol
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
IgG purified

Alternate Names for Adenine Nucleotide Translocase 1 Antibody

  • AAC1
  • Adenine nucleotide translocator 1
  • ADP
  • ADP/ATP translocase 1
  • ANT 1
  • ANT1adenine nucleotide translocator 1 (skeletal muscle)
  • ATP carrier protein 1
  • ATP carrier protein, heart/skeletal muscle isoform T1
  • ATP carrier protein, heart/skeletal muscle
  • heart/skeletal muscle ATP/ADP translocator
  • PEO2
  • PEO3
  • solute carrier family 25 (mitochondrial carrier; adenine nucleotidetranslocator), member 4
  • Solute carrier family 25 member 4
  • T1ANT

Background

Adenine Nucleotide Translocase 1 catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. It is is a key component of the mitochondrial permeability transition pore (PT pore) complex and is also one of the most abundant proteins in the mitochondrion making up approximately 10% of all mitochondrial proteins. Originally described as an ADP/ATP exchange factor, ANT1 has also been shown to be required for bax mediated apoptosis. This is effected by binding of bax to residues 105-156 of ANT1, presumably resulting in maintaining the PT pore in an open conformation. Interaction with bax is not required for ANT1 pro-apoptotic activity as overexpression of the ANT1 protein also leads to the induction of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SLC25A4
Entrez
Uniprot