ADAMTS4 Antibody

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Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP1-02415] - Staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 6 ...read more

Product Details

Summary
Reactivity Hu, Bt, Ca, Eq, Mk, Pm, PoSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

ADAMTS4 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from internal region of human ADAMTS4.
Specificity
Human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAMTS8 (53%).
Predicted Species
Porcine (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ADAMTS4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 6 ug/ml

Reactivity Notes

Orangutan, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Elephant (95%), Mouse (89%), Bovine (84%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ADAMTS4 Antibody

  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4
  • ADAM-TS 4
  • ADAMTS2
  • ADAMTS-2
  • ADAMTS4
  • ADAM-TS4
  • ADAMTS-4
  • ADMP-1
  • ADMP-1EC 3.4.24.82
  • Aggrecanase 1
  • aggrecanase-1
  • EC 3.4.24
  • KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4

Background

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ADAMTS4
Entrez
Uniprot