ABCG2/CD338 Antibody (BXP-34)

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Product Details

Summary
Product Discontinued
View other related ABCG2/CD338 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-42557
    • Availability
      Product Discontinued

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ABCG2/CD338 Antibody (BXP-34) Summary

Immunogen
The antibody reacts with the Breast Cancer Resistance Protein antigen.
Marker
Stem Cell Marker
Specificity
BXP-34 Mab was selected after immunization with the mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR. BXP-34 reacts with an internal epitope of BCRP, a 70 kD transmembrane half-transporter which is involved in multidrug resistance. BXP-34 did not cross-react with the human MDR1, MRP1, MRP2, MRP5 gene products.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ABCG2
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
BXP-34 has potential value for detection of BCRP-mediated drug-resistance in human tumor samples. Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: BXP-34 (use 1:20) on acetone fixed frozen sections can be followed by incubation with rabbit anti-mouse IgG (1:25) and a monoclonal mouse APAAP complex (1:50). BXP-34 cannot be used on formaldehyde-fixed paraffin-embedded human tissues and tumours. Also in Western blot the Mab is unreactive. Flow cytometry: use dil 1:20. Permeabilisation necessary.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.1% Sodium Azide
Purity
Protein A or G purified

Alternate Names for ABCG2/CD338 Antibody (BXP-34)

  • ABC transporter
  • ABC15
  • ABCG2
  • ABCP
  • ABCPMGC102821
  • ATP-binding cassette sub-family G member 2
  • ATP-binding cassette transporter G2
  • ATP-binding cassette, sub-family G (WHITE), member 2
  • BCRP
  • BCRP1
  • BCRPMRX
  • BMDP
  • Breast cancer resistance protein
  • CD338 antigen
  • CD338
  • CDw338
  • EST157481
  • mitoxantrone resistance protein
  • Mitoxantrone resistance-associated protein
  • MXR
  • MXRMXR1
  • placenta specific MDR protein
  • Placenta-specific ATP-binding cassette transporter

Background

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ABCG2
Entrez