ABCD1 Antibody (EPR1362)

Product Discontinued

ABCD1 Antibody (EPR1362) Summary

• Immunogen: A synthetic peptide corresponding to residues in mouse ABCD1 was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: ABCD1
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100 - 250
  • Western Blot 1:1000-1:10000

Reactivity Notes

Reacts with: Mouse Does not react with Rat, Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for ABCD1 Antibody (EPR1362)

• Adrenoleukodystrophy protein
• ALDATP-binding cassette sub-family D member 1
• ALDPadrenoleukodystrophy
• AMNABC42
• ATP-binding cassette, sub-family D (ALD), member 1

Background

Chemokines are a large family of small secreted proteins that regulate migration of white blood cells. Based on the arrangement of the first two of the four conserved cysteine residues, chemokines are classified into four subfamilies, CXC, CC, C and recently identified CX3C (1). The CC chemokines, in which the first 2 cysteines are adjacent, usually act on monocytes, T lymphocytes, and, in some cases, eosinophils, basophils, or mast cells. The CC subfamily proteins are 70 to 100 amino acids long, have 25 to 75% identity with each other, and include novel member of the CC chemokine subfamily, designated ABCD1 (SCYA22). The ABCD1 shares 28 to 34% identity with other CC chemokines and contains the characteristic 4-cysteine motif and 9 other highly conserved residues (2). The activated T cell-attracting CC chemokine CCL22 is expressed by stimulated B cells and mature dendritic cells (DC). Both identical and distinct proteins contribute to expression of CCL22 in DC and B cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCD1
• Uniprot:
  • O88430()