4-1BB Ligand/TNFSF9 Antibody Summary
Synthetic peptide, corresponding to amino acids 50-100 of Human 4-1BBL.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline (PBS), approx. pH 7.2.
0.05% Sodium Azide
Immunogen affinity purified
- Western Blot 1:500-1:1000
- Immunocytochemistry/Immunofluorescence 1:50-1:200
Western blot (WB) analysis of 4-1BBL (R69) pAb in extracts from HUVEC cells. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Alternate Names for 4-1BB Ligand/TNFSF9 Antibody
- 41BB Ligand
- 4-1BB ligand
- homolog of mouse 4-1BB-L
- receptor 4-1BB ligand
- tumor necrosis factor (ligand) superfamily, member 9
- tumor necrosis factor ligand superfamily member 9
TNFSF9, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. TNFSF9 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between TNFSF9 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. Crosslinking of the TNFSF9 ligand induces apoptosis in resting lymphocytes. In contrast, TNFSF9 regulates peripheral monocyte survival by inducing a cytokine release profile, and is mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Soluble forms of TNFSF9 are found in sera from patients with rheumatoid arthritis and may provide a negative control mechanism for immune responses.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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