26S proteasome subunit 9 Antibody

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Product Details

Summary
Product Discontinued
View other related 26S proteasome subunit 9 Primary Antibodies

Order Details


    • Catalog Number
      NB100-1949
    • Availability
      Product Discontinued

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26S proteasome subunit 9 Antibody Summary

Immunogen
Synthetic peptide corresponding to the C-terminal of human p27.
Localization
Nuclear
Specificity
p27
Clonality
Polyclonal
Host
Rabbit
Gene
PSMD9
Purity
IgG purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1/200
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
Positive Control
Jurkat Lysate (NB800-PC2)
NIH 3T3 Lysate (NB800-PC8)
HeLa Lysate (NB800-PC1)
Kidney Lysate (NB820-59709)
26S proteasome subunit 9 Lysate (NBL1-14906)

Reactivity Notes

Cross-reacts with Human, Rat and Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
1 ml PBS containing 0.2% gelatin
Preservative
0.1% Sodium Azide
Concentration
0.2 mg/ml
Purity
IgG purified

Alternate Names for 26S proteasome subunit 9 Antibody

  • 26S proteasome non-ATPase regulatory subunit 9
  • p27
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
  • Rpn4

Background

The progression through the cell cycle is regulated by cyclins and their cognate Cdks by promoting cell cycle transitions (1,2,3). This orderly progression can be inhibited by a family of proteins known as CDK inhibitors (CDIs) that bind to cyclin/Cdk complexes and halt cell division (3). p21 (also designated WAF1/Cip1) is one has been shown to inhibit the activity of each member of the cyclin/Cdk family and over expression of this protein inhibits the proliferation of mammalian cells (5). The expression of p21 is inducible by a wide range of stress stimuli and its transcription can be enhanced by p53 (6). Another member of the CDIs is p27 (also known as Kip1), which also sees up regulation in response to antimitogenic stimuli (7). The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes, like cyclin D1/Cdk4 (4,8). An additional CDI has been found to bind Cdk4 and Cdk6, p16 (INK4A), and when such complexes are formed, the progression of the cell cycle is halted (9). It has become increasingly clear that p16 is a very important tumor suppressor gene whose frequent loss occurs early in many human cancers. p16 is a major target in carcinogenesis that is rivaled in frequency only by p53 (10).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol PSMD9
Entrez