14-3-3 tau/theta Antibody

Images

 
Western Blot: 14-3-3 tau/theta Antibody [NBP1-71900] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-14-3-3-theta antibody used for IP at 6 mcg/mg lysate. ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-71900
    • Availability
      Product Discontinued

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14-3-3 tau/theta Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 100 and 150 of human 14-3-3 protein theta using the numbering given in entry NP_006817.1 (GeneID 10971).
Clonality
Polyclonal
Host
Rabbit
Gene
YWHAQ
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunoprecipitation 2-10 mcg/mg

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for 14-3-3 tau/theta Antibody

  • 14-3-3 protein tau
  • 14-3-3 protein T-cell
  • 14-3-3 protein theta
  • 1433 theta
  • 14-3-3 theta
  • 14-3-3,1C5
  • HS1 protein
  • HS1
  • Protein HS1
  • protein tau
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, thetapolypeptide
  • YWHAQ

Background

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 beta, gamma, episilon, zeta, eta, theta and sigma. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol YWHAQ
Entrez
Uniprot