14-3-3 sigma/Stratifin [p Ser248] Antibody

Product Discontinued

14-3-3 sigma/Stratifin [p Ser248] Antibody Summary

• Immunogen: Synthetic peptides derived from Cter domain of Stratifin protein containing phosphoserine 248
• Modification: p Ser248
• Specificity: Antiserum reacts specifically with the human 27 kDa Stratifin pS248 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SFN
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000

Reactivity Notes

Reacts with Human. May cross-react with Stratifin from mouse, rat and other species due to sequence identity.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Antiserum
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute with 0.2 ml distilled water.

Alternate Names for 14-3-3 sigma/Stratifin [p Ser248] Antibody

• 14-3-3 protein sigma
• 1433 sigma
• 14-3-3 sigma
• Epithelial cell marker protein 1
• HME1
• SFN
• stratifin
• YWHAS

Background

14-3-3 family of proteins is composed of seven isotypes, beta, gamma, zeta, epsilon, tau, eta, and sigma, that play critical roles in cell signaling events that control cell cycle progression, transcriptional alterations, and apoptosis (1-4). 14-3-3 proteins were the first signaling molecules to be identified as specific phosphoserine/threonine binding proteins (1). 14-3-3 can serve as a direct regulator of its target by altering the function of the protein (3). 14-3-3 protein targets include the signalling intermediates Raf, MEKK, PI-3 kinase and IRS-1, cell cycle proteins CDK2, Wee1, and Cdc25, and apoptosis proteins BAD and ASK-1 (3,4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SFN