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Wnt Receptor Signaling Pathway Bioinformatics

The Wnt receptor signaling pathway is a highly preserved pathway that can lead to one of three functions depending on which form of pathway is signaled by the Wnt molecule. The canonical pathway leads to regulation of gene transcription relating to development, cell polarity, and neuron formation, the non-canonical planar cell polarity pathway maintains the cytoskeleton and therefore the shape of the cell, and the calcium pathway works to keep cellular calcium levels consistent. The pathway begins with a Wnt signaling molecule, which causes the Dsh molecule to bond on the receptor FZD on the inside of the cell and become phosphorylated. The GSK-3beta complex binds to the activated Dsh, and the beta-catenin molecule is freed. When the levels of beta-catenin get high enough, they translocate to the nucleus and bind to DNA to initiate the transcription of the previously mentioned functions. The Wnt signaling pathway has been shown to play a role in embryonic development through stem cell pluripotency, and abnormal rates of this process can result in disorders including tumor progression and type II diabetes.

Wnt Receptor Signaling Pathway Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Wnt Receptor Signaling Pathway below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 471 products for the study of the Wnt Receptor Signaling Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

AF1120
Frizzled‑1 was detected in immersion fixed frozen sections of embryonic mouse intestine (13 d.p.c.) using 15 µg/mL Goat Anti-Mouse Frizzled‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1120) overnight at <BR>4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Mouse
Applications WB, IHC

3 Publications
AF1617

Goat Polyclonal
Species Human
Applications WB

6 Publications
NBP2-37510
Western Blot: LRP-5 Antibody (2B11) [NBP2-37510] - Western blot analysis using LRP5 mAb against human LRP5 (AA: 1422-1615) recombinant protein. (Expected MW is 20.8 kDa)Flow Cytometry: LRP-5 Antibody (2B11) [NBP2-37510] - Flow cytometric analysis of HeLa cells using LRP5 mouse mAb (green) and negative control (red).

Mouse Monoclonal
Species Human
Applications WB, ELISA, Flow

AF3014

Goat Polyclonal
Species Human
Applications WB, IHC, Block

3 Publications
NBP2-67168
Immunocytochemistry/Immunofluorescence: STAT2 Antibody (JF0884) [NBP2-67168] - Staining STAT2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.Immunohistochemistry-Paraffin: STAT2 Antibody (JF0884) [NBP2-67168] - Analysis of paraffin-embedded mouse skin tissue using anti-STAT2 antibody. Counter stained with hematoxylin.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-91821
Western Blot: DCI Antibody [NBP1-91821] - Analysis using Anti-ECI1 antibody NBP1-91821 (A) shows similar pattern to independent antibody NBP1-91822 (B).Immunohistochemistry-Paraffin: DCI Antibody [NBP1-91821] - Staining of human kidney.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-41185
Western Blot: BRCA1 Antibody (17F8) [NBP1-41185] - Non-transfected (-) and transfected (+) 293T whole cell extracts (60 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with BRCA1 antibody [17F8] - ChIP grade.Chromatin Immunoprecipitation: BRCA1 Antibody (17F8) [NBP1-41185] - ChIP grade BRCA1 antibody 6B4  and BRCA1 antibody 17F8 were used for ChIP assay. The 6B4 and 17F8 mixture (3 microgram each), or normal mouse IgG (6 microgram) were incubated with HeLa chromatin extract (100 umicrogram each) in the ChIP assay. Enrichment of genomic DNA on a BRCA1 target gene promoter (HMGA2) was validated by a Q-PCR assay.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ChIP, ELISA

9 Publications
NB300-284
Western Blot: Myosin Heavy Chain Antibody (3-48) [NB300-284] - analysis of total cardiac myosin expression in tissue lysates of rat heart (lanes 1-5), liver (lanes 6-7), and lung (lanes 8-9). Increasing amounts of total protein were loaded as follow: lanes 1, 6 and 8: 0 ug; lane 2: 50 ug; lanes 3, 7 and 9: 250 ug; lane 5: 500 ug. (anti-cMHC was used at 1:500; secondary antibody: Goat anti-mouse IgG Fc-HRP; 1:5000)Immunohistochemistry-Paraffin: Myosin Heavy Chain Antibody (3-48) [NB300-284] - Formaldehyde-fixed paraffin-embedded (FFPE) Tissue Slides. Human heart ventricle following immunostaining with cMHC 3-48 and irrelevant NeuAc monoclonal antibody at low microscopical magnification.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     2 Reviews

8 Publications
NBP2-38161
Immunohistochemistry-Paraffin: SH3BGR Antibody [NBP2-38161] - Staining of human skin shows low expression as expected.Immunohistochemistry-Paraffin: SH3BGR Antibody [NBP2-38161] - Staining of human heart muscle shows high expression.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

NB100-353
Western Blot: BubR1 Antibody (8G1) [NB100-353] - BUBR1 detected in HeLa cell lysate using NB 100-353.Immunocytochemistry/Immunofluorescence: BubR1 Antibody (8G1) [NB100-353] - Immunofluorescence of an asynchronous cycling population of human cells (U2OS) with NB100-353. No signal is detected from interphase cells, whereas cells undergoing mitosis accumulate BubR1 at the kinetochores. Image reveals kinetochores at prometaphase. Image courtesy of Luke Hughes-Davies and Rhiannon Jade, Gurdon Institute, Cambridge, UK.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

8 Publications
AF1408
Western blot shows lysates of human colon tissue, PC‑12 rat adrenal pheochromocytoma cell line, A549 human lung carcinoma cell line, and SK‑BR‑3 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Rat Cystatin B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1408) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=    Western  blot shows lysates of HEK293T human embryonic kidney parental cell line and  Cystatin B knockout HEK293T cell line (KO). PVDF membrane was probed with  1 µg/mL of Goat Anti-Human/Rat Cystatin B Antigen  Affinity-purified Polyclonal Antibody (Catalog # AF1408) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human, Rat
Applications WB, Simple Western, IHC

2 Publications
NBP2-33609
Western Blot: SH3BGRL Antibody [NBP2-33609] - Analysis in human cell lines SK-MEL-30 and A-431 using anti-SH3BGRL antibody. Corresponding SH3BGRL RNA-seq data are presented for the same cell lines. Loading control: anti-HSP90B1.Immunocytochemistry/Immunofluorescence: SH3BGRL Antibody [NBP2-33609] - Immunofluorescent staining of human cell line MCF7 shows localization to vesicles.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NB100-509
Western Blot: INTS1 Antibody [NB100-509] - Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-INT1 antibodyA300-361A used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.Immunoprecipitation: INTS1 Antibody [NB100-509] - Detection of human INTS1 (INT1) by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-INT1 antibody NB100-509 used for IP at 3 ug per reaction. INT1 was also immunoprecipitated by rabbit anti-INT1 antibody from Company B. For blotting immunoprecipitated INT1, NB100-509 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IP

AF1286
    Western  blot shows lysates of human skin tissue. PVDF membrane was probed with  1 µg/mL of Goat Anti-Human Cystatin E/M Antigen  Affinity-purified Polyclonal Antibody (Catalog # AF1286) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Simple  Western lane view shows lysates of human skin tissue, loaded at  0.2 mg/mL. A specific band was detected for Cystatin E/M at  approximately 13 kDa (as indicated) using 50 µg/mL of Goat  Anti-Human Cystatin E/M Antigen Affinity-purified Polyclonal  Antibody (Catalog # AF1286) followed by 1:50 dilution of HRP-conjugated  Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, IHC

     1 Review

4 Publications
NB100-619
Western Blot: RECQ1 Antibody [NB100-619] - Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Affinity purified rabbit anti-RecQ1 antibody NB100-619 used for WB at 0.1 ug/mL. Detection: Chemiluminescence with an exposure time of 1 second.Immunohistochemistry: RECQ1 Antibody [NB100-619] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- RecQ1 at 1:5000 (0.2 ug/mL). Detection: DAB

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     3 Reviews

2 Publications
NBP1-46175
Western Blot: Orc2 Antibody [NBP1-46175] - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells.  Antibodies: Affinity purified rabbit anti-ORC2 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  ORC2 was also immunoprecipitated by rabbit anti-ORC2 antibody NBP1-46175, which recognizes an upstream epitope.Immunohistochemistry-Paraffin: Orc2 Antibody [NBP1-46175] - Section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-ORC2 used at a dilution of 1:1,000 (0.2ug/ml) Detection: DAB staining using Immunohistochemistry Accessory Kit.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
AF2390
Western blot shows lysates of human heart tissue. PVDF membrane was probed with 0.2 µg/mL of Goat Anti-Human Thrombospondin‑4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2390) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of human heart tissue, loaded at 0.2 mg/mL. A specific band was detected for Thrombospondin‑4 at approximately 158 kDa (as indicated) using 2 µg/mL of Goat Anti-Human Thrombospondin‑4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2390) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human
Applications WB, Simple Western

     4 Reviews

7 Publications
NBP1-31558
Western Blot: NKX2.5 Antibody [NBP1-31558] - Various whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with Nkx2.5 antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: NKX2.5 Antibody [NBP1-31558] - Paraformaldehyde-fixed mouse ESC D3, using antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

2 Publications