The Wnt receptor signaling pathway is a highly preserved pathway that can lead to one of three functions depending on which form of pathway is signaled by the Wnt molecule. The release of the Wnt protein is strongly regulated, and occurs with the acylation by palmitoloeyl groups including the endoplasmic-reticulum-resident acyltransferase Porcupine. This Wnt has then been shown to accumulate near secreting cells as well as form multimeric complexes, which can allow for both short-and long-range diffusion respectively. The pathway begins with a Wnt signaling molecule, which causes the Dsh molecule to bond on the receptor FZD on the inside of the cell and become phosphorylated. The GSK-3beta complex binds to the activated Dsh, and the beta-catenin molecule is freed. When the levels of beta-catenin get high enough, they translocate to the nucleus and bind to DNA to initiate the transcription of the previously mentioned functions. The Wnt signaling pathway has been shown to play a role in embryonic development through stem cell pluripotency, and abnormal rates of this process can result in disorders including tumor progression and type II diabetes.
Wnt Protein Secretion Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Wnt Protein Secretion below!
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We have 491 products for the study of the Wnt Protein Secretion Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.