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Wnt Protein Secretion Pathway Bioinformatics

The Wnt receptor signaling pathway is a highly preserved pathway that can lead to one of three functions depending on which form of pathway is signaled by the Wnt molecule. The release of the Wnt protein is strongly regulated, and occurs with the acylation by palmitoloeyl groups including the endoplasmic-reticulum-resident acyltransferase Porcupine. This Wnt has then been shown to accumulate near secreting cells as well as form multimeric complexes, which can allow for both short-and long-range diffusion respectively. The pathway begins with a Wnt signaling molecule, which causes the Dsh molecule to bond on the receptor FZD on the inside of the cell and become phosphorylated. The GSK-3beta complex binds to the activated Dsh, and the beta-catenin molecule is freed. When the levels of beta-catenin get high enough, they translocate to the nucleus and bind to DNA to initiate the transcription of the previously mentioned functions. The Wnt signaling pathway has been shown to play a role in embryonic development through stem cell pluripotency, and abnormal rates of this process can result in disorders including tumor progression and type II diabetes.

Wnt Protein Secretion Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Wnt Protein Secretion below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 491 products for the study of the Wnt Protein Secretion Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.

Western Blot: GRP177 Antibody [NBP1-59013] - Human Liver cell lysate, concentration 0.2-1 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB

Western Blot: mu Opioid R/OPMR1 Antibody [NBP1-31180] - Sample(30 ug of whole cell lysate) A:A431 B:H1299 7.5% SDS PAGE, antibody diluted at 1:500.Immunohistochemistry-Paraffin: mu Opioid R/OPMR1 Antibody [NBP1-31180] - Paraffin-embedded Cal27 xenograft, using antibody at 1:500 dilution.

Rabbit Polyclonal
Species Human
Applications WB, DB, ICC/IF

     1 Review

2 Publications
Western Blot: HEY1 Antibody [NBP2-27152] - Analysis of Hey1 in mouse embryo brain lysate using 1) preimmune sera at 1:5000 dilution and 2) purified NBP2-27152. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Rabbit Polyclonal
Species Mouse
Applications WB

Immunohistochemistry: MMP-7 Antibody [NBP1-99123] -  MMP7 antibody was tested in human breast cancer using DAB with hematoxylin counterstain. The image on the right had the antibody blocked by preincubation with immunizing peptide.

Rabbit Polyclonal
Species Human, Mouse
Applications IHC, IHC-P

Western Blot: LEF1 Antibody [NBP1-86960] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY402529)Immunocytochemistry/Immunofluorescence: LEF1 Antibody [NBP1-86960] - Immunofluorescent staining of human cell line U-251MG shows positivity in nucleus but not nucleoli.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication
Western Blot: Slug Antibody [NBP2-27182] -  Western blot analysis of extracts from HepG2 cells using Slug antibody (NBP2-27182) at 1:1000.Immunohistochemistry: Slug Antibody [NBP2-27182] - Immunohistochemistry analysis of liver cancer using Slug antibody (NBP2-27182) at 1:25. Image objective 400x.

Rabbit Polyclonal
Species Human, Mouse, Canine
Applications WB, IHC, IHC-P

1 Publication
Functional (Inhibition): NFkB p105/p50 Inhibitor Peptide Set [NBP2-29323] - TLR5/NF-kB/SEAPorter HEK 293 (NBP2-26277) cells were plated in 96-well plates at 5 x 10^4 cells/well for 16 h. Cells were preincubated with different concentrations (0, 1, 5, 10, 25 and 50 uM) of Inhibitory Peptide (NBP2-29323) and Control Peptide (NBP2-29334) for 1 h. Cells were then stimulated with 1 ng/ml Flagellin (NBP2-25289) for 24 h. Secreted alkaline phosphatase (SEAP) was analyzed using SEAPorter Assay Kit (NBP2-25285). *p < 0.05 versus control peptide at the corresponding concentrations (Mann-Whitney U test).

Species Human, Mouse, Rat
Applications Func-Inh

9 Publications
Western Blot: HMGA2 Antibody (763) [NBP2-43640] - Whole cell extract (30 ug) was separated by 15% SDS-PAGE, and the membrane was blotted with HMGA2 antibody [763] diluted at 1:1000.Immunocytochemistry/Immunofluorescence: HMGA2 Antibody (763) [NBP2-43640] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: HMGA2 protein stained by HMGA2 antibody [763]  diluted at 1:200. Red: phalloidin, a cytoskeleton marker, diluted at 1:50.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC-P

Western Blot: E-Cadherin Antibody (7H12) [NBP2-19051] - Western blot analysis of E-Cadherin in LNCAP (1), A431 (2), DU145 (3), PC-3 (4), MCF-7 (5), PC-12 (6), NIH/3T3 (7), C6 (8) and COS7 (9) cell lysate.Immunocytochemistry: E-Cadherin Antibody (7H12) [NBP2-19051] - Human colonic tissue was stained with E-Cadherin antibody. Image from verified customer review.

Mouse Monoclonal
Species Human, Mouse, Monkey
Applications WB, ELISA, Flow

     5 Reviews

3 Publications

Related Genes

The Wnt Protein Secretion Pathway has been researched against:

Related Diseases

The Wnt Protein Secretion Pathway has been studied in relation to diseases such as:

Related PTMs

The Wnt Protein Secretion Pathway has been studied in relation to posttranslational modifications (PTMs) including: