Transforming growth factor beta (TGF-beta) is a protein that helps control functions in cells such as differentiation and proliferation. It works as an anti-proliferative factor during early stages of oncogenesis in epithelial cells. Abnormal amounts of TGF-beta can lead to the progression of some diseases and disorders including cancer, heart disease, and Parkinson’s disease. TGF-beta can be secreted by various cells including macrophages when they are in a latent form and bound to certain proteins including CD68. TGF-beta can be secreted due to inflammatory stimuli and different stages of myogenesis. Other factors that lead to the secretion of TGF-beta include high glucose and sodium levels, angiotensin II, and high rates of TGF-beta secretion have been seen in areas of the body including mesangial cells.
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Transforming Growth Factor-beta Secretion below!
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We have 2458 products for the study of the Transforming Growth Factor-beta Secretion Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.