Transforming growth factor beta (TGF-beta) is a protein that helps control functions in cells such as differentiation and proliferation. It works as an anti-proliferative factor during early stages of oncogenesis in epithelial cells. Abnormal amounts of TGF-beta can lead to the progression of some diseases and disorders including cancer, heart disease, autoimmune diseases, and Parkinson’s disease. When TGF-beta is initially secreted, it is in a latent form that needs to be activated in order to carry out its functions. There are several factors that have been shown to contribute to the activation of TGF-beta, including proteases, reactive oxygen species, pH, radiation exposure, and thrombospondin-1. The activation of this protein most often results in the TGF-beta signaling cascade to commence, leading to the growth and proliferation of various cells.
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We have 926 products for the study of the Transforming Growth Factor Beta Activation Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.