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Single Strand Break Repair Pathway Bioinformatics

Disease and disorder research has been conducted in relation to the Single Strand Break Repair Pathway and Ataxia, Malignant Neoplasms, Dna Breaks, Single-stranded, Neoplasms, Ataxia Telangiectasia. The study of the Single Strand Break Repair Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. The Single Strand Break Repair Pathway has been researched in relation to Dna Repair, Dna Replication, Cell Cycle, Aging, Sensitization. The Single Strand Break Repair Pathway complements our catalog of research reagents including antibodies and ELISA kits against PARP1, XRCC1, APTX, SBF2, GDAP1.

Top Research Reagents

We have 931 products for the study of the Single Strand Break Repair Pathway that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NB100-165
Western Blot: XRCC3 Antibody [NB100-165] - (A) Human XRCC3 (hXRCC3) expression was down regulated by siRNA in human transofrmed fibroblasts. (B) XRCC3 was inactivated in human colon cancer cells by gene targeting [Yoshihara et all., 2004, EMBO J., 23 (3), 670-680]. hXRCC3 was detected by WB using XRCC3 antibody (NB100-165). The star indicates non-specific cross-reactivity of the antibody. Image provided by confirmed customer review.Western Blot: XRCC3 Antibody [NB100-165] - Detection of XRCC3 (38 kDa) from HeLa cell extract using NB100-165 (1:2500). Lanes 1 and 2 contain HTC116 and Hela whole cell extracts, respectively.

Rabbit Polyclonal
Species Human, Drosophila, Hamster
Applications ICC/IF (-), WB, IP

     1 Review

15 Publications
NBP1-48002
Western Blot: SSB Antibody (OTI2C8) [NBP1-48002] - Analysis of extracts (35ug) from 9 different cell lines by using anti-SSB monoclonal antibody.Immunocytochemistry/Immunofluorescence: SSB Antibody (OTI2C8) [NBP1-48002] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SSB.

Mouse Monoclonal
Species Human, Canine, Monkey
Applications WB, ICC/IF, IHC

NBP1-84430
Western Blot: GDAP1 Antibody [NBP1-84430] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)<br/>Lane 5: Human liver tissueImmunocytochemistry/Immunofluorescence: GDAP1 Antibody [NBP1-84430] - Immunofluorescent staining of human cell line A549 shows localization to cytosol & mitochondria. Antibody staining shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP1-87154
Western Blot: XRCC1 Antibody [NBP1-87154] - Analysis in U2OS cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presentedWestern Blot: XRCC1 Antibody [NBP1-87154] - Analysis in A-549 cells transfected with control siRNA, target specific siRNA probe #1 and #2. Remaining relative intensity is presented. Loading control: Anti-GAPDH.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

5 Publications
NBP1-87257
Western Blot: PNK Antibody [NBP1-87257] - Analysis in U-138MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-PNKP antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Western Blot: PNK Antibody [NBP1-87257] - In vitro therapeutic efficacy and in vivo pharmacodynamics. Western blotting showing the levels of each of the 6 kinases in the signature, in addition to their non-phosphorylated controls where applicable, in 10 human TNBC cell lines, the transplantable murine TNBC tumor model 4T1, and 2 patient-derived xenografts (PDXs). The three targets against which clinical-grade drugs are available are highlighted in red. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/s41467-018-05742-z), licensed under a CC-BY license.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

9 Publications
NBP1-94712
Western Blot: Senataxin Antibody [NBP1-94712] - Input: HeLa whole cell lysate. Beads without antibody IP control. IP: IP from HeLa lysate.Immunocytochemistry/Immunofluorescence: Senataxin Antibody [NBP1-94712] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.5% Triton-X100. The cells were incubated with anti-Senataxin at 2 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) NB100-690 was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

     1 Review

7 Publications
NBP2-13283
Western Blot: SBF2 Antibody [NBP2-13283] - Analysis in human cell line BEWO.Immunohistochemistry-Paraffin: SBF2 Antibody [NBP2-13283] - Staining of human prostate shows weak cytoplasmic positivity in smooth muscle cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-16182
Western Blot: DNA Ligase IV Antibody [NBP2-16182] - Mouse tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with DNA ligase IV antibody diluted at 1:500.Immunocytochemistry/Immunofluorescence: DNA Ligase IV Antibody [NBP2-16182] - Analysis of paraformaldehyde-fixed HeLa, using antibody at 1:500 dilution.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

1 Publication
NB100-1607
Immunocytochemistry/Immunofluorescence: Myelin Protein Zero Antibody [NB100-1607] - Immunohistochemical staining of P-zero on a 4.0% paraformaldehyde-fixed, paraffin-embedded tissue section through the sciatic nerve of an adult mouse. (Green) P0 concentration was 1:1000 dilution, followed by fluorescein-labeled goat anti-chicken IgY (1:500 dilution). Red is actin. Blue is DAPI nuclear counterstain. Immunohistochemistry: Myelin Protein Zero Antibody [NB100-1607] - In the image (a lower power tissue section through an adult sciatic nerve), Myelin Protein Zero (brown staining) can be seen in all of the myelinating Schwann cells.

Chicken Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

15 Publications
NB110-57130
Immunocytochemistry/Immunofluorescence: TRF-2 Antibody [NB110-57130] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton X-100. The cells were incubated with antibody at a 1:200 dilution overnight at 4 degrees Celsius and detected with DyLight 488 (Green) at a 1:500 dilution. Alpha tubulin was used as a co-stain at a 1:1000 dilution and detected with Dylight 550 (Red). Nuclei were detected with DAPI (Blue) at 2.0 ug/ml in 1X PBS. Cells were imaged using a 40X objective.Simple Western: TRF-2 Antibody [NB110-57130] - Lane view shows a specific band for TRF2 in 1.0 mg/mL of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, DB

     2 Reviews

135 Publications
NBP2-38600
Immunohistochemistry-Paraffin: DNA Polymerase beta Antibody [NBP2-38600] - Staining in human testis and liver tissues using anti-POLB antibody. Corresponding POLB RNA-seq data are presented for the same tissues.Western Blot: DNA Polymerase beta Antibody [NBP2-38600] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Human cell line RT-4

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     1 Review

NBP2-43728
Western Blot: Collagen XI alpha 2 Antibody (473) [NBP2-43728] - Various tissue extracts (50 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with COL11A2 antibody [473]  diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (NBP2-19382) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: Collagen XI alpha 2 Antibody (473) [NBP2-43728] - A431 cells were fixed in ice-cold MeOH for 5 min. Green: COL11A2 protein stained by COL11A2 antibody [473] diluted at 1:500. Blue: Hoechst 33342 staining.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

NB100-98689
Immunocytochemistry/Immunofluorescence: CAMP/Cathelicidin Antibody [NB100-98689] - AKB-4924 pretreatment enhances production of nitric oxide and host defense peptides during UPEC infection. Representative images illustrating the distribution of murine cathelicidin (red) and nuclei (DAPI, blue) in the mucosa of UTI89 infected bladders with vehicle or AKB-4924 pre-treatment (n = 6). Upper panel scale bar = 50 um. Bottom panel: higher magnitude focused on the uroepithelial cell layer of bladder. Scale bar = 25 um. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.ppat.1004818) licensed under a CC-BY license.AKB-4924 pretreatment enhances production of nitric oxide and host defense peptides during UPEC infection. (G) Representative images illustrating the distribution of murine cathelicidin (red) and nuclei (DAPI, blue) in the mucosa of UTI89 infected bladders with vehicle or AKB-4924 pre-treatment (n = 6). Upper panel scale bar = 50 um. Bottom panel: higher magnitude focused on the uroepithelial cell layer of bladder. Scale bar = 25 um. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25927232), licensed under a CC-BY licence.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, DB, ICC/IF

8 Publications
NBP2-80913
Immunohistochemistry: PMP22 Antibody (Hu1) - Azide and BSA Free [NBP2-80913] - Staining of PMP22 (brown) in dorsal root ganglion and spinal roots in 20 week fetal spinal cord preparation from rhesus monkey. Image from the standard format of this antibody.

Mouse Monoclonal
Species Human, Primate, Bovine (Negative)
Applications WB, IHC, IHC-P

NBP2-98661
Western Blot: Aprataxin Antibody [NBP2-98661] - Anti-Aprataxin rabbit polyclonal antibody at 1:500 dilution. Lane A: HeLa Whole Cell Lysate. Lane B: A549 Whole Cell Lysate. Lane C: 293 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 40 kDa. Observed band size: 40 kDaImmunocytochemistry/Immunofluorescence: Aprataxin Antibody [NBP2-98661] - Immunofluorescence staining of Aprataxin in PC3 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human Aprataxin polyclonal antibody (dilution ratio 1:200) at 4C overnight. Then cells were stained with the Alexa Fluor(R)488-conjugated Goat Anti-rabbit IgG Secondary antibody (green). Positive staining was localized to Nucleus.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC-P

H00008898-M03
Western Blot: MTMR2 Antibody (4G6) [H00008898-M03] - Analysis of MTMR2 expression in PC-12 (Cat # L012V1).Western Blot: MTMR2 Antibody (4G6) [H00008898-M03] - Analysis of MTMR2 expression in HeLa (Cat # L013V1).

Mouse Monoclonal
Species Human, Rat
Applications WB, ELISA

1 Publication
NB100-81642
Western Blot: TDP1 Antibody [NB100-81642] - Detection of Human TDP1 on HeLa whole cell lysate using NB100-81642. TDP1 was  also immunoprecipitated by rabbit anti-TDP1 antibody NB100-81643.Immunohistochemistry-Paraffin: TDP1 Antibody [NB100-81642] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- TDP1 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

2 Publications