Regulation Of Wnt Receptor Signaling Pathway Bioinformatics
The Wnt receptor signaling pathway is a highly preserved pathway that can lead to one of three functions depending on which form of pathway is signaled by the Wnt molecule. The canonical pathway leads to regulation of gene transcription relating to development, cell polarity, and neuron formation, the non-canonical planar cell polarity pathway maintains the cytoskeleton and therefore the shape of the cell, and the calcium pathway works to keep cellular calcium levels consistent. The pathway begins with a Wnt signaling molecule, which causes the Dsh molecule to bond on the receptor FZD on the inside of the cell and become phosphorylated. The GSK-3beta complex binds to the activated Dsh, and the beta-catenin molecule is freed. When the levels of beta-catenin get high enough, they translocate to the nucleus and bind to DNA to initiate the transcription of the previously mentioned functions. The Wnt signaling pathway has been shown to play a role in embryonic development through stem cell pluripotency, and abnormal rates of this process can result in disorders including tumor progression and type II diabetes. There exist certain factors that are involved in the regulation of the Wnt pathway that include wntless, Dally, and glypican 3 to inhibit the secretion and diffusion of the Wnt protein. There are also proteins that can bind to the FZD receptor that works as antagonists such as Dkk, WIF-1, Frzb, and secreted Frizzled-related proteins. Conversely, factors such as Norrin and R-Spondin2 may work as activators of the Wnt pathway without the Wnt molecule.
Regulation Of Wnt Receptor Signaling Pathway Bioinformatics Tool
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