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Regulation Of Wnt Receptor Signaling Pathway Bioinformatics

The Wnt receptor signaling pathway is a highly preserved pathway that can lead to one of three functions depending on which form of pathway is signaled by the Wnt molecule. The canonical pathway leads to regulation of gene transcription relating to development, cell polarity, and neuron formation, the non-canonical planar cell polarity pathway maintains the cytoskeleton and therefore the shape of the cell, and the calcium pathway works to keep cellular calcium levels consistent. The pathway begins with a Wnt signaling molecule, which causes the Dsh molecule to bond on the receptor FZD on the inside of the cell and become phosphorylated. The GSK-3beta complex binds to the activated Dsh, and the beta-catenin molecule is freed. When the levels of beta-catenin get high enough, they translocate to the nucleus and bind to DNA to initiate the transcription of the previously mentioned functions. The Wnt signaling pathway has been shown to play a role in embryonic development through stem cell pluripotency, and abnormal rates of this process can result in disorders including tumor progression and type II diabetes. There exist certain factors that are involved in the regulation of the Wnt pathway that include wntless, Dally, and glypican 3 to inhibit the secretion and diffusion of the Wnt protein. There are also proteins that can bind to the FZD receptor that works as antagonists such as Dkk, WIF-1, Frzb, and secreted Frizzled-related proteins. Conversely, factors such as Norrin and R-Spondin2 may work as activators of the Wnt pathway without the Wnt molecule.

Regulation Of Wnt Receptor Signaling Pathway Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Regulation Of Wnt Receptor Signaling Pathway below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 714 products for the study of the Regulation Of Wnt Receptor Signaling Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NB100-1347
Immunohistochemistry-Paraffin: TSSC3 Antibody [NB100-1347] - Staining of paraffin embedded Human Placenta. Antibody at 3.75 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Immunohistochemistry-Paraffin: TSSC3 Antibody [NB100-1347] - Staining of paraffin embedded Human Prostate. Antibody at 3.75 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human
Applications IHC, IHC-P, PEP-ELISA

1 Publication
NB120-6405
Immunocytochemistry/Immunofluorescence: MHC Class I Antibody (OX18) [NB120-6405] - Major histocompatibility complex (MHC) I and II as well as Transporter associated with antigen presentation II (TAPII) were analyzed, using immunocytochemistry on rat Schwann cells (SCs). Corresponding merges are shown in the bottom rows. Treatment of SCs with IL-17 was performed at concentrations of 0.5 and 50 ng/mL. Graphs to the right show densitometry quantification. SCs showed expression of MHCI > TAPII > MHCII, which increased after IL-17 treatment. MHCI was mainly detected in the cytoplasm and the expression increased in a dose-dependent manner after IL-17 treatment, significant for 0.5 ng/mL and 50 ng/mL (**P <=0.01). Image collected and cropped by CiteAb from the following publication (http://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-11-63), licensed under a CC-BY licence.Immunohistochemistry-Paraffin: MHC Class I Antibody (OX18) [NB120-6405] - Analysis of FFPE rat brain cerebellum using MHC Class I (OK18) antibody at 1:200 on a Bond Rx autostainer (Leica Biosystems). The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary antibody for 30 minutes and Bond Polymer Refine Detection (Leica Biosystems) with DAB was used for signal development followed by counterstaining with hematoxylin. Whole slide scanning and capturing of representative images was performed using Aperio AT2 (Leica Biosystems). Endothelial staining was observed. Staining was performed by Histowiz.

Mouse Monoclonal
Species Rat
Applications EM, ELISA, Flow

33 Publications
NB100-598
Western Blot: BRCA1 Antibody (RAY) [NB100-598] - Analysis of BRCA1 on MCF7 lysate.Immunocytochemistry/Immunofluorescence: BRCA1 Antibody (RAY) [NB100-598] - BRCA (RAY) antibody was tested in MCF-7 cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 (red).

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

4 Publications
NB100-353
Western Blot: BubR1 Antibody (8G1) [NB100-353] - BUBR1 detected in HeLa cell lysate using NB 100-353.Immunocytochemistry/Immunofluorescence: BubR1 Antibody (8G1) [NB100-353] - Immunofluorescence of an asynchronous cycling population of human cells (U2OS) with NB100-353. No signal is detected from interphase cells, whereas cells undergoing mitosis accumulate BubR1 at the kinetochores. Image reveals kinetochores at prometaphase. Image courtesy of Luke Hughes-Davies and Rhiannon Jade, Gurdon Institute, Cambridge, UK.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

     1 Review

8 Publications
NBP2-35224
SDS-Page: Human PTHLH/PTHrP Protein [NBP2-35224]


Species Human
Applications Func, PAGE

AF1120
Frizzled‑1 was detected in immersion fixed frozen sections of embryonic mouse intestine (13 d.p.c.) using 15 µg/mL Goat Anti-Mouse Frizzled‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1120) overnight at <BR>4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Mouse
Applications WB, IHC

3 Publications
AF1408
Western blot shows lysates of human colon tissue, PC‑12 rat adrenal pheochromocytoma cell line, A549 human lung carcinoma cell line, and SK‑BR‑3 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Rat Cystatin B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1408) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=    Western  blot shows lysates of HEK293T human embryonic kidney parental cell line and  Cystatin B knockout HEK293T cell line (KO). PVDF membrane was probed with  1 µg/mL of Goat Anti-Human/Rat Cystatin B Antigen  Affinity-purified Polyclonal Antibody (Catalog # AF1408) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human, Rat
Applications WB, Simple Western, IHC

2 Publications
AF1286
    Western  blot shows lysates of human skin tissue. PVDF membrane was probed with  1 µg/mL of Goat Anti-Human Cystatin E/M Antigen  Affinity-purified Polyclonal Antibody (Catalog # AF1286) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Simple  Western lane view shows lysates of human skin tissue, loaded at  0.2 mg/mL. A specific band was detected for Cystatin E/M at  approximately 13 kDa (as indicated) using 50 µg/mL of Goat  Anti-Human Cystatin E/M Antigen Affinity-purified Polyclonal  Antibody (Catalog # AF1286) followed by 1:50 dilution of HRP-conjugated  Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, IHC

     1 Review

4 Publications
AF1617

Goat Polyclonal
Species Human
Applications WB

8 Publications
5439-DK/CF
<P align=left>1 μg/lane of Recombinant Human Dkk-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing major bands at 33-38 kDa. Multiple bands in gel are due to variable glycosylation.</P>Recombinant  Human Wnt‑3a (Catalog # <a class=


Species Human
Applications BA

77 Publications
1109-N1/CF
<P align=left>1 μg/lane of Recombinant Mouse Netrin-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band at 83 kDa.


Species Mouse
Applications Bind

32 Publications

Related Genes

The Regulation Of Wnt Receptor Signaling Pathway has been researched against:

Related Diseases

The Regulation Of Wnt Receptor Signaling Pathway has been studied in relation to diseases such as:

Related PTMs

The Regulation Of Wnt Receptor Signaling Pathway has been studied in relation to posttranslational modifications (PTMs) including: