Regulation Of Programmed Cell Death Pathway Bioinformatics
Programmed cell death is a process that can either be regulatory or as a result of an external stress on a system of the body. There are two forms of programmed cell death: apoptosis and autophagy. Both forms undergo multiple cascades that lead to the death of a cell, and they both must receive some intrinsic or extrinsic signal to initiate the process. The positive regulation of programmed cell death is mediated by several proteins including RPR, HID, GRIM, and the YihE protein kinase that all work to initiate pathways that lead to the activation of the cell-destroying caspases. The induction of programmed cell death is currently being studied as a treatment for several diseases including cancer, and recent publications show cannabinoids to be factors that induce cell death in cancerous cells, while leaving normal cells alone. The negative regulation of apoptosis is done by the blocking of the Fas receptor or introduction of a caspase-3 inhibitor. Autophagy is the degradation of organelles inside the cell by lysosomal machinery, and can help with regulating cellular energy levels. The negative regulation of autophagy is maintained with the continuous activation of the mTOR pathway, which is done so by sensing proper cellular levels of growth factors, amino acids, oxygen, and energy. The negative regulation of cell death is necessary to ensure that too many cells are not destroyed, for if they are serious diseases and disorders could arise such as those associated with neurodegeneration.
Regulation Of Programmed Cell Death Bioinformatics Tool
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