Regulation Of Nuclear Division Pathway Bioinformatics
Nuclear division occurs during both meiosis and mitosis, and is the process of the nuclear from one cell dividing and separating to form two new cells. In the case of mitosis, the division results in the two nuclei being genetically identical to the parent nucleus. In meiosis, however, two divisions occur, which results in four haploid cells being formed from a diploid parent cell. The regulation of nuclear division is primarily controlled by cyclins, which accumulate in the cell during the growth phases of the cell cycle. When there is a high enough level of cyclins, they being to bind with CDK1 to for a mitotic promoting factor (MPF). MPFs can be activated by the phosphorylation and binding of a Thr-161 protein and the reverse can happen through inhibitory phosphorylations of Thr-14 and Thr-15 complexes. MPFs, along with other complexes such as the anaphase promoting complex, allow nuclear division to occur. The degradation of cyclin inhibits division of the nucleus, resulting in these proteins being essential in the regulation of the cell cycle.
Regulation Of Nuclear Division Bioinformatics Tool
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