Neurogenesis is the generation of neurons from stem and progenitor cells. The majority of neurogenesis occurs in pre-natal development, but recent research has found neurogeneration to occur in adults in two regions of the brain: the subventricular zone of the lateral ventricles, which ultimately lead to the olfactory bulb, and the subgranular zone of the dentate gyrus located in the hippocampus. The majority of these new neurons die quickly after generation, but some are able to migrate into the surrounding brain tissue. The rate of successful neurogenesis depends on several factors including testosterone and acetylcholine, exercise, CNS injuries, and chronic stress. There are also other biological factors that are involved in the regulation of neurogenesis, including dopamine, the FGF receptor-inhibiting PACAP, and the epigenetic regulation pathway. Neurogenesis has been shown to have a positive effect on memory retention and capacity as well as on the side effects of stress.
Regulation Of Neurogenesis Bioinformatics Tool
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