Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Bioinformatics
The epidermal growth factor receptor signaling pathway (EGFR pathway) occurs when an epidermal growth factors binds to the receptor. Ligand binding occurs and the shape of the EGFR changes, which allows for dimerization and phosphorylation of the tyrosine kinase domain. The phosphorylation can lead to the signaling molecule RAS to become activated, which activates a signaling cascade that results in the MEK molecule signaling transcription. There are multiple other signaling cascades that lead to transcription as well such as the MAPK and JNK pathways. There has also been seen to be crosstalk between the InR/TOR pathway and the EGFR pathway, more specifically the InR/TOR pathway is able to regulate various components of the EGFR pathway. Signaling in the InR/TOR pathway can therefore help control the growth and proliferation of cells dependent on epidermal growth factors. The EGFR pathway is commonly seen in solid tumor growth and metastasis in cancers such as thyroid cancer.
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Bioinformatics Tool
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