Regulation Of Anti-apoptosis Pathway Bioinformatics
Anti-apoptosis is a form of cell survival, which can be mediated by a variety of proteins including NF kappa-B, Bcl-2 and the baculoviral inhibitor survivin. Sphingosine kinase has also been shown to have a positive regulation of anti-apoptosis, through the AKT pathway which inhibits the caspase blockers XIAP and FLIP. Anti-apoptosis is an essential event in cases of degenerative diseases, but can conversely lead to a very poor prognosis in patients with cancer, for apoptosis is necessary to inhibit the growth of tumors. Further studies have found regulatory factors concerning apoptosis, including cyclin D1 and Francisella tularensis, which induces a macrophage-involved apoptosis. The inhibition of apoptosis can cause very rapid tumor growth, and the process of eliminating these inhibitors is a treatment method currently being studied by scientists.
Regulation Of Anti-apoptosis Bioinformatics Tool
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