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Regulation Of Angiogenesis Pathway Bioinformatics

Angiogenesis is the process of the formation of new blood vessels from those that already exist. Angiogenesis is an important function in the oxygenation of tissues, and can help in various functions including wound healing and the treatment of vascular diseases such as heart disease, high blood pressure, and diabetes. An abnormal rate of angiogenesis, however, can cause many problems including the proliferation of cancerous tumors, diabetic ulcers, and cardiovascular diseases. Many scientists have studied factors of angiogenesis such as macrophages, and treatments have been created that work in the negative regulation of angiogenesis, including sphingosine-1 phosphate and TCF8. Consequently, researchers are also looking to inhibit proteins that facilitate angiogenesis, such as VEGF. There also exist factors that work on the positive regulation of angiogenesis, such as the hypoxia-inducible factor, that allows for blood vessels to grow and further distribute oxygen throughout a body suffering from hypoxia.

Regulation Of Angiogenesis Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Regulation Of Angiogenesis below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 3217 products for the study of the Regulation Of Angiogenesis Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NB100-689
Immunohistochemistry-Paraffin: COX-2 Antibody [NB100-689] - Formalin fixed paraffin embedded colon carcinoma stained with COX-2 antibody (NB100-689).Simple Western: COX-2 Antibody [NB100-689] - Simple Western lane view shows a specific band for COX2 in 1.0 mg/ml of Rat Brain at an antibody concentration of 1:100.  This experiment was performed under reducing conditions using the 12-230 kDa separation system.  Image provided through customer review.

Rabbit Polyclonal
Species Human, Rat
Applications WB, Simple Western, IHC

     1 Review

33 Publications
NB100-105
Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1 alpha induction by CoCl2 on Caki-1 cell lysate. WB image submitted by a verified customer review.Knockout Validated: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1 alpha was detected in immersion fixed DFO treated Hela cells (left) but was not detected in HIF-1 knockout HeLa cells (right) using Mouse Anti-human HIF-1 alpha monoclonal antibody (Catalog # NB100-105) at 25 ug/mL for 3 hours at room temperature. Cells were stained using a NorthernLights (TM) 557-conjugated Donkey Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to nuclei.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ChIP

     45 Reviews

939 Publications
NBP2-22203
Western Blot: ERK1 Antibody (1E5) [NBP2-22203] - Western blot analysis of whole cell lysates from (1) MCF7 (2) NIH3T3 cell lines using ERK1 antibody (clone 1E5) at 1:1000 dilution. The signal was developed using HRP labeled goat-anti Mouse secondary antibody with ECL based detection. Immunocytochemistry/Immunofluorescence: ERK1 Antibody (1E5) [NBP2-22203] - Analysis of NIH/3T3 cells using ERK1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

AF644
Recombinant Mouse VEGFR2/KDR/Flk‑1 Fc Chimera (Catalog # <a class=VEGFR2 was detected in acetone fixed cryosections of mouse kidney tissue using Goat Anti-Mouse VEGFR2/KDR/Flk-1 Polyclonal Antibody (Catalog # AF644) for 50 minutes at room temperature. Tissues were stained with rabbit anti-goat secondary<br>antibody and HRP polymer-conjugated anti-rabbit IgG followed by AEC+Substrate Chromogen (red) followed by counterstaining with hematoxylin (blue). Experiments were carried out and the image was provided by Dr. Grietje Molema, University Medical Center Groningen, The Netherlands.

Goat Polyclonal
Species Mouse
Applications WB, Flow, IHC

     4 Reviews

54 Publications
AF887
Western blot shows lysates of NIH‑3T3 mouse embryonic fibroblast cell line untreated (-) or treated (+) with 100 ng/mL Human PDGF (Catalog #<A class=NoLineLink href=Simple Western lane view shows lysates of MCF‑7 human breast cancer cell line and A549 human lung carcinoma cell line untreated (-) or treated (+) with 100 ng/mL Recombinant Human IGF‑I (Catalog # <A class=NoLineLink href=

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, IHC

28 Publications
DTSP10
 Thrombospondin-1 [HRP]


Species Human
Applications ELISA

     1 Review

37 Publications
DVE00
 VEGF [HRP] VEGF [HRP]


Species Human
Applications ELISA

     26 Reviews

607 Publications
DPG00
 PLGF [HRP] PLGF [HRP]


Species Human
Applications ELISA

     1 Review

68 Publications
923-AN/CF


Species Human
Applications BA

64 Publications
210-TA
1 µg/lane of Recombinant Human TNF-alpha  was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.Recombinant Human TNF-alpha  (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.


Species Human
Applications BA

     36 Reviews

726 Publications
233-FB/CF
Recombinant Human FGF basic/FGF2/bFGF (146 aa) (Catalog # 233-FB/CF) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The activity is approximately 3-fold greater than the top competitor's FGF basic (146 aa).1 µg/lane of Recombinant Human FGF basic/FGF2/bFGF (146 aa) was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.


Species Human
Applications BA

459 Publications
DANG20
 Angiopoietin-2 [HRP] Angiopoietin-2 [HRP]


Species Human
Applications ELISA

     4 Reviews

90 Publications
D8000C
 CXCL8/IL-8 [HRP] CXCL8/IL-8 [HRP]


Species Human
Applications ELISA

     8 Reviews

391 Publications
DVEC00
 VEGF-C [HRP] VEGF-C [HRP]


Species Human
Applications ELISA

     3 Reviews

45 Publications
DVR100C
 VEGFR1/Flt-1 [HRP] VEGFR1/Flt-1 [HRP]


Species Human
Applications ELISA

     2 Reviews

75 Publications
NBP2-67360
Knockout Validated: ERK2 Antibody (SZ25-01) [NBP2-67360] - Lysates of HeLa WT and MAPK1 KO were prepared, and 30 ug of protein were processed for immunoblot with the indicated Mitogen-activated protein kinase 1 antibodies. The Ponceau stained transfers of each blot are shown. Antibody dilution used: 1/1000. Predicted band size: 41 kDa. Image, protocol and testing courtesy of YCharOS Inc. (ycharos.com).Knockout Validated: ERK2 Antibody (SZ25-01) [NBP2-67360] - HeLa WT and MAPK1 KO cells were labelled with a green or a far-red fluorescent dye, respectively. WT and KO cells were mixed and plated to a 1:1 ratio on coverslips. Cells were stained with the indicated Mitogen-activated protein kinase 1 antibodies and with the corresponding Alexa-fluor 555 coupled secondary antibody. Acquisition of the green (identification of WT cells), red (antibody staining) and far-red (identification of KO cells) channels was performed. Representative images of the red (grayscale) channels are shown.WT and KO cells are outlined with yellow and magenta dashed line, respectively. Antibody dilution used: 1/1000. Bars = 10 um. Image, protocol and testing courtesy of YCharOS Inc. (ycharos.com).

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review


Related PTMs

The Regulation Of Angiogenesis Pathway has been studied in relation to posttranslational modifications (PTMs) including: