The p38 MAPK cascade originates from a ligand binding to a receptor tyrosine kinase, which leads to dimerization and the self-phosphorylation of the kinases. GRB2 and SOS bind to the kinase complex, which leads to the activation of Ras as GDP is phosphorylated to GTP. This can lead to the activation of multiple cascades, and in the case of the p38 pathway, various forms of MMK are activated, which in turn activated p38 isoforms and induce several activities inside the nucleus. Some of these activities include stress response, cytokine production, and the inhibition of cell cycle progression in cells such as adipocytes, myoblasts, and neurons. The p38 MAPK pathway also plays a role in the pathogenesis of autoimmune diseases, as it plays a role in the sustained inflammation of these diseases by CD4 T cells.
P38mapk Cascade Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on P38mapk Cascade below!
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We have 503 products for the study of the P38mapk Cascade Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.