Osteoblasts are the cells that are responsible for bone formation. Conversely, osteoclasts are cells that break down bone tissue. Osteoblasts come from immature progenitor cells called osteoprogenitors, which are induced by various growth factors, including bone morphogenetic proteins (BMPs), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-beta). Together, BMPs, FGF, PDGF and TGF-beta increase bone production. In a recent study, it was reported that hESC treatment with BMP4 and FGF2 enhanced osteoblast differentiation (PMID: 23206696). The Wnt/beta-Catenin Pathway may play a role in osteoblast differentiation (PMID: 17572649).
Osteoblast Differentiation Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Osteoblast Differentiation below!
For more information on how to use Laverne, please read the How to Guide.
We have 1490 products for the study of the Osteoblast Differentiation Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.